The NEI 40th Anniversary Symposia Series
Structural and Functional Imaging with Optical Coherence Tomography
David Huang, M.D., Ph.D.
Optical coherence tomography (OCT) systems for eye imaging have improved dramatically with the introduction of Fourier-domain technology. For many retinal diseases, clinical reading of the detailed cross-sectional OCT images is sufficient for diagnosis and management decisions. In other applications, however, automated quantitative measurements of 3-dimensional structures are needed. We have developed algorithms to map and measure corneal thickness and power. These measurements are useful in the diagnosis of keratoconus (a risk factor for LASIK complications and in the calculation of intraocular lens (IOL) power in post-LASIK cataract surgery. We have also developed methods to map and analyze the thickness of the retinal ganglion cell complex (GCC) in the macula with OCT. Clinical results show this new type of measurement will help diagnose and track the progression of glaucoma.
Beyond structural imaging, OCT can also provide measurements of retinal blood flow, an indicator or retinal function. We have developed a double circular scan pattern for OCT measurement of retinal blood flow. This method allows, for the first time, measurement of total retinal blood flow in absolute units up to 6 times per second. This allows for comparison of blood flow measurements between subjects and between visits. Preliminary results in normal subjects, glaucoma subjects, and subjects with diabetic retinopathy or anterior ischemic optic neuropathy are presented.
David Huang, M.D., Ph.D.
Associate Professor of Ophthalmology And Biomedical Engineering
University Of Southern California
Charles C. Manger III, M.D. Chair in Corneal Laser Surgery
Director, Center for Ophthalmic Optics & Lasers
Medical Director, Doheny Laser Vision Center
Dr. David Huang is the Charles C. Manger, III, MD Chair in Corneal Laser Surgery and associate professor of ophthalmology and biomedical engineering at the University of Southern California (USC). He is also the Medical Director of the Doheny Laser Vision Center (www.dohenylaser.com) at Doheny Eye Institute (www.doheny.org). Dr. Huang earned the MD degree from Harvard University and a PhD in Medical Engineering and Medical Physics from Massachusetts Institute of Technology. He received ophthalmology residency training at USC and fellowship training in cornea, external disease and refractive surgery at Emory University School of Medicine. Prior to joining the USC faculty, Dr. Huang was on the staff of the Cole Eye Institute of the Cleveland Clinic.
Dr. Huang is known for his innovations in applying laser and optical technology to eye diseases. He is a co-inventor of optical coherence tomography (OCT), an imaging technology that has been applied to the measurement of eye structures with unprecedented precision. He has 8 issued patents and 6 pending patents in the areas of OCT, tissue engineering and corneal laser surgery. He has been the principal investigator of 4 National Institutes of Health research grants. He serves on the governing board, editorial board, program committee or advisory committee of 6 professional organizations. He has published more than 60 peer-reviewed articles and edited 2 books. Dr. Huang has received an Achievement Award from the American Academy of Ophthalmology and was selected as one of the Best Doctors in America (www.bestdoctors.com) and is listed on www.trustedlasiksurgeons.com, a directory service that screens LASIK surgeons based on research experience and premier patient care. Dr. Huang leads the Center for Ophthalmic Optics and Lasers (www.COOLLab.net) at USC.