Immunopathology Section

Recent Publications

Selected Review Articles

C.C. Chan, Q. Li: Immunopathology of uveitis. Br J Ophthalmol 82:91-96, 1998. PubMed

G. Adamus, C.C. Chan: Experimental autoimmune uveitides: Multiple antigens, diverse diseases. In Caspi, R.R. (ed.): The eye: Immunity and autoimmunity. Int Rev Immunol 21:209-229, 2002. PubMed

C.C. Chan: Molecular pathology of primary intraocular lymphoma. Tranas Am Ophthalmol Soc 101:275-292, 2003. PubMed

C.C. Chan, D.J. Wallace: Intraocular lymphoma: Update on diagnosis and management. Cancer Control 11:285-295, 2004. PubMed

J. Tuo, C.M. Bojanowski, C.C. Chan: Genetic factors of age-related macular degeneration. Prog Ret Eye Res 23:229-249, 2004. PubMed

C.C. Chan, R.J. Ross, D. Shen, X. Ding, Z. Majumdar, C.M. Bojanowski, M. Zhou, N. Salem, Jr., R. Bonner, J. Tuo: Ccl2/Cx3cr1 deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res 40:124-128, 2008. PubMed

M. Patel, C.C. Chan: Immunopathological aspects of age-related macular degeneration. Sem Immunopathol 30:97-110, 2008. PubMed

X. Ding, X. Ding, M. Patel, C.C. Chan: Molecular pathology of age-related macular degeneration. Prog Ret Eye Res 28:1-18, 2009. PubMed

Peer Reviewed Journal Articles

E. Tsilou, M. Zhou, W. Gahl, P.C. Sieving, C.C. Chan: Ophthalmic manifestations and histopathology of infantile nephropathic cystinosis: Report of a case and review of the literature. Surv Ophthalmol 52:97-105, 2007. PubMed

X. Liang, D. Shen, Y. Huang, C. Yin, C.M. Bojanowski, Z. Zhuang, C.C. Chan: Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease. Ophthalmology 114:147-56, 2007 PubMed

C.C. Chan, A.B.D. Collins, E.Y. Chew: Molecular pathology of the eyes with von Hippel-Lindau (VHL) disease: A review. Retina 27:1-7, 2007. PubMed

A.M. Mansour, S.H. Uwaydat, C.C. Chan: Long-term follow-up in Bietti cyrstallin dystrophy. Eur J Ophthalmol 17:680-682, 2007. PubMed

R.J. Ross, C.M. Bojanowski, J.J. Wang, E.Y. Chew, E. Rochtchina, F.L. Ferris, III, P. Mitchell, C.C. Chan, J. Tuo: The LOC38775 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci 48:1128-1132, 2007. PubMed

N. Cassoux, A. Giron, B. Bodaghi, T.H.C. Tran, S. Baudet, F. Davy, C.C. Chan, P. LeHoang, H. Merle-Beral: IL-10 measurement in aqueous humor for screening patients with suspecion of primary intraocular lymphoma (PIOL). Invest Ophthalmol Vis Sci 48:3253-3259, 2007. PubMed

M. Shah, E.J. Holland, C.C. Chan: Resolution of autoimmune polyglandular syndrome associated keratopathy with keratolimbal stem cell transplantation: Case report and historical literature review. Cornea 26:632-635, 2007 PubMed

J.A. Gonzales, C.C. Chan: Biopsy techniques and yields in diagnosing primary intraocular lymphoma. Int Ophthalmol 27:241-250, 2007. PubMed

S.K. Kurup, G. Levy-Clarke, K.R. Calvo, E.S. Jaffe, R.B. Nussenblatt, C.C. Chan: Primary diffuse large B cell lymphoma of the spleen with coincident serous retinal detachment responsive to corticosteroids. Clin Experiment Ophthalmol 35:468-472, 2007. PubMed

J. Tuo, C.M. Bojanowski, M. Zhou, D. Shen, R.J. Ross, K.I. Rosenberg, D. J. Cameron, C. Yin, J.A. Kowalak, Z. Zhuang, K. Zhang, C.C. Chan: Murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 48:3827-3836, 2007. PubMed

D. Sredni-Kenigsbuch, C.C. Chan, M. David: A novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MARK expression in atopic dermatitis. J Dermatol Sci 50:232-235, 2008. PubMed

R.J. Ross, V. Verma, K.I. Rosenberg, C.C. Chan, J. Tuo: Genetic markers and biomarkers for age-related macular degeneration. Future Drugs-Expert Rev Ophthalmol 2:443-457, 2007. PubMed

B.P. Brooks, D.M. Larson, C.C. Chan, S. Kjellstrom, R.S. Smith, M.A. Crawford, L. Lamoreux, M. Huizing, R. Hess, X. Jiao, F.J. Hejtmancik, A. Maminishkis, S.W.M. John, R. Bush, W.J. Pavan: Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci 48:3905-3913, 2007. PubMed

T. Schlesinger, B. Appukuttan, T. Hwang, L. Atchaneeyakasul, C.C. Chan, Z. Zhuang, J.T. Stout, D.J. Wilson: Internal en bloc resection and genetic analysis of retinal capillary hemangioblastoma. Arch Ophthalmol 125:1189-1193, 2007. PubMed

C.C. Chan, D. Shen, M. Zhou, R.J. Ross, X. Ding, K. Zhang, W.R. Green, J. Tuo: Human HtrA1 in the archived eyes with age-related macular degeneration. Trans Am Ophthalmol Soc 105:92-98, 2007. PubMed

M. Zhou, D. Shen, J.E. Head, E.Y. Chew, P. Chévez-Barrios, W.R. Green, C.C. Chan: Ocular clusterin expression in von Hippel-Lindau disease. Mol Vis 13:2129-2136, 2007. PubMed

J.E. Head, D. Shen, M. Santiago-Maysonet, R.J. Bishop, C.C. Chan: Ocular pathology of uncommon hematologic malignancies: a case series. J Med Case Rep 28:158, 2007. PubMed

J.J. Wang, R.J. Ross, J. Tuo, G. Burlutsky, A.G. Tan, C.C. Chan, E.J. Favaloro, A. Williams, P. Mitchell: The LOC387715 polymorphism, inflammatory markers, smoking and age-related macular degeneration: A population-based case-control study. Ophthalmology 115:693-699, 2008. PubMed

Z. Lin, X. Zhang, J. Tuo, Y. Guo, B. Green, C.C. Chan, W. Tan, Y. Huang, W. Ling, F.F. Kadlubar, B. Ning, D. Ling: Variant of the Cockayne syndrome B gene ERCC6 confers risk of lung cancer. Hum Mutat 29:113-122, 2008. PubMed

J. Tang, R.A. Stevens, A.A. Okada, M. Chin, R.B. Nussenblatt, C.C. Chan: Association of antiretinal antibodies in acute annular outer retinopathy. Arch Ophthalmol 126:130-132, 2008. PubMed

V. Verma, D. Shen, P.C. Sieving, C.C. Chan: The role of infectious agents in the etiology of ocular adnexal neoplasia. Surv Ophthalmol 53:312-331, 2008. PubMed

G. Levy-Clarke, D. Greenman, P.C. Sieving, G. Byrnes, D. Shen, R.B. Nussenblatt, C.C. Chan: Ophthalmic manifestations, cytology, immunohistochemistry and molecular analysis of intraocular metastatic T-cell lymphoma: Report of a case and review of the literature. Surv Ophthalmol 53:285-295, 2008. PubMed

A.A. Herzlich, J. Tuo, C.C. Chan: Peroxisome proliferator–activated receptor and age-related macular degeneration. PPAR Res 2008:389507, 2008. PubMed

W. Wong, S. Yeh, C.C. Chan, R.E. Kalina, J.L. Kinyoun, H.R. Coleman, E.Y. Chew: Retinal neovascularization as a manifestation of ocular von Hippel-Lindau (VHL) disease. Arch Ophthalmol 126:637-643, 2008. PubMed

T. Sauer, M. Patel, C.C. Chan, J. Tuo: Unfolding the therapeutic potential of chemical chaperones for age-related macular degeneration. Future Drugs-Expert Rev Ophthalmol 3:29-42, 2008. PubMed

H.N. Sen, C.C. Chan, G. Byrnes, R.N. Fariss, R.B. Nussenblatt, R.R. Buggage: Intravitreal methotrexate resistance in a patient with primary intraocular lymphoma. Ocul Immunol Inflamm 16:29-33, 2008. PubMed

X. Ding, A. Herzlich, R. Bishop, J. Tuo, C.C. Chan: Ocular toxicity of fludarabine, a purine analog. Future Drugs-Expert Rev Ophthalmol 3:97-109, 2008. PubMed

R.J. Ross, M. Zhou, D. Shen, R.N. Fariss, X. Ding, C.M. Bojanowski, J. Tuo, C.C. Chan: Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration. Exp Eye Res 86:675-683, 2008. PubMed

P. Muranski, A. Boni, P.A. Antony, L. Cassard, K.R. Irvine, a. Kaiser, C.M. Paulos, D.C. Palmer, C.E. Touloukian, K. Ptak, L. Gattinoni, C. Wrzesinski, C.S. Hinrichs, K. Kerstann, L. Feigenbaum, C.C. Chan, N.P. Restifo: Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112:362-373, 2008. PubMed

D.C. Palmer, C.C. Chan, L. Gattinoni, C. Wrzesinski, C.M. Paulos, C.S. Hinrichs, D.J. Powell Jr., C.A. Klebanoff, S.E. Finkelstein, R.N. Fariss, Z. Yu, R.B. Nussenblatt, S.A. Rosenberg, N.P. Restifo: Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity. Proc Natl Acad Sci USA 105:8061-8066, 2008. PubMed

V. Verma, T. Sauer, C.C. Chan, M. Zhou, C. Zhang, A. Maminishkis, D. Shen, J. Tuo: Constancy of ERp29 expression in cultured retinal pigment epithelial cells in the Ccl2/Cx3cr1 deficient mouse model of age-related macular degeneration. Curr Eye Res 33:701-7, 2008. PubMed

J. Tuo, R.J. Ross, G.F. Reed, Q. Yan, J.J. Wang, C.M. Bojanowski, E.Y. Chew, X. Feng, T.W. Olsen, F.L. Ferris, III, P. Mitchell, C.C. Chan: The HtrA1 promotor polymorphism, smoking and age-related macular degeneration in multiple case-control samples. Ophthalmology. 2008 Aug 20. [Epub ahead of print]. PubMed

A.A. Herzlich, S. Yeh, D. Shen, X. Ding, G. Uzel, S.M. Holland, C.C. Chan: Identification of Pseudomonas aeruginosa DNA in a chorioretinal lesion associated with chronic granulomatous disease. J Clin Pathol 61:1229-1230, 2008.

L. Cimino, C.C. Chan, D. Shen, L. Masini, F. Ilariucci, M. Masetti, S. Asioli, L. Cappuccini, A. Sartori: Ocular involvement in nasal natural killer T-cell lymphoma. Int Ophthalmol 29:275-279, 2009. PubMed

X. Ding, R.J. Bishop, A. A. Herzlich, M. Patel, C.C. Chan: Limbal stem cell deficiency arising from systemic chemotherapy with hydroxycarbamide. Cornea 28:221-223, 2009. PubMed

I.M. MacDonald, L. Russell, C.C. Chan: Choroideremia: New findings from ocular pathology and review of recent literature. Surv Ophthalmol 54:401-407, 2009. PubMed

D. Shen, J. Tuo, M. Patel, A.A. Herzlich, X. Ding, E.Y. Chew, C.C. Chan: Chlamydia pneumoniae infection, complement factor H variants, and age-related macular degeneration. Br J Ophthalmol 93:405-408, 2009. PubMed

G. Levy-Clarke, X. Ding, S. Yeh, S. Gangaputra, T. Goodglick, G. Byrnes, R.B. Nussenblatt, C.C. Chan: Recalcitrant granulomatous sclerouveitis in a patient with granulomatous ANCA associated vasculitis. Ocul Immunol Inflamm 17:83-87, 2009. PubMed

C.C. Chan, T.C. Sauer: Ocular imaging in primary retinal lymphoma. Am J Ophthalmol 147:764-765, 2009. PubMed

L.J. Faia, C.C. Chan: Primary intraocular lymphoma. Arch Pathol Lab Med 133:1228-1232, 2009. PubMed

X. Cao, R.J. Bishop, F. Forooghian, Y. Cho, R.N. Fariss, C.C. Chan: Autoimmune retinopathy in systemic lupus erythematosus: Histopathologic features. Open Ophthalmol J 3:15-19, 2009. PubMed

J. Tuo, R.J. Ross, A.A. Herzlich, D. Shen, X. Ding, M. Zhou, S.L. Coon, N. Hussein, N. Salem, Jr., C.C. Chan: A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am J Pathol 175:799-807, 2009. PubMed

S.E. Coupland, C.C. Chan, J.R. Smith: Pathophysiology of retinal lymphoma. Ocul Immunol Inflamm 17:227-237, 2009. PubMed

Supplemental Materials

C.C. Chan, J.A. Gonzales: Primary Intraocular Lymphoma. World Scientific Publishing Co., Singapore, London, Hackensack NJ, 2007. World Scientific

C.C. Chan, J.A. Gonzales, F.A. Jakobiec, A.A. Hidayat: Chapter 102. Intraoculoar lymphoproliferations simulating uveitis. In Albert and Jakobiec’s Principles and Practice of Ophthalmology. Third edition. D. Albert, J. Miller (eds); Elsevier, Toronto, Canada, 2008. Elsevier

M. Zhou, R.J. Ross, C.C. Chan: Chapter III. New research communications on intraocular lymphoma markers. In Progress in Tumor Marker Research. L.I. Swenson (ed); Nova Science Publisher, Hauppauge, NY, 2007; pp.67-82. Nova

A.A. Herzlich, M. Patel, T. Sauer, C.C. Chan: Chapter 2. Retinal anatomy and pathology; Section 1. Retinal Molecular Biology. In Retinal Pharmacotherapy. Nguyen, Rodrigues, Farah, Mieler (ed.); Elsevier London, UK. 2008. Elsevier

T.C. Sauer, C.C. Chan: Chapter 36. Masquerade syndrome. In Uveitis. Imaging Techniques and Text. Gupta, Gupta, Herbort, Khairallah (ed.); Jaypee Brothers Medical Publisher (P) Ltd. 2008; pp. 746-755.

W.T. Wong, E.Y. Chew, C.C. Chan: Chapter 7. Juxtapapillary Manifestations of von Hippel-Lindau (VHL) Disease. In Optic Nerve Disease Research Perspectives. B.D. Lewis, C.J. Davies (ed); Nova Science Publisher, Hauppauge, NY, 2008; pp. 235-256. Nova