Immunopathology Section

Recent Publications

Selected Review Articles

C.C. Chan, Q. Li: Immunopathology of uveitis. Br J Ophthalmol 82:91-96, 1998. PubMed

G. Adamus, C.C. Chan: Experimental autoimmune uveitides: Multiple antigens, diverse diseases. In Caspi, R.R. (ed.): The eye: Immunity and autoimmunity. Int Rev Immunol 21:209-229, 2002. PubMed

C.C. Chan: Molecular pathology of primary intraocular lymphoma. Tranas Am Ophthalmol Soc 101:275-292, 2003. PubMed

J. Tuo, C.M. Bojanowski, C.C. Chan: Genetic factors of age-related macular degeneration. Prog Ret Eye Res 23:229-249, 2004. PubMed

M. Patel, C.C. Chan: Immunopathological aspects of age-related macular degeneration. Sem Immunopathol 30:97-110, 2008. PubMed

X. Ding, X. Ding, M. Patel, C.C. Chan: Molecular pathology of age-related macular degeneration. Prog Ret Eye Res 28:1-18, 2009. PubMed

H.L. Ramkumar, J. Zhang, C.C. Chan: Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Ret Eye Res 29:169-190, 2010. PubMed

Y. Wang, V.M. Wang, C.C. Chan: The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment. Eye 25:127-139, 2011. PubMed

C.C. Chan, J.L. Rubenstwin, S.E. Coupland, J.L. Davis, J.W. Harbour, P.B. Johnston, N. Cassoux, V. Touitou, J.R. Smith, T.T. Batchelor, J.S. Pulido: Primary vitreoretinal lymphoma: A report from an international primary central nervous system lymphoma collaborative group symposium. The Oncologist 16:1589-1599, 2011. PubMed

Peer Reviewed Journal Articles

D. Shen, J. Tuo, M. Patel, A.A. Herzlich, X. Ding, E.Y. Chew, C.C. Chan: Chlamydia pneumoniae infection, complement factor H variants, and age-related macular degeneration. Br J Ophthalmol 93:405-408, 2009. PubMed

L. Cimino, C.C. Chan, D. Shen, L. Masini, F. Ilariucci, M. Masetti, S. Asioli, L. Cappuccini, A. Sartori: Ocular involvement in nasal natural killer T-cell lymphoma. Int Ophthalmol 29:275-279, 2009. PubMed

X. Ding, R.J. Bishop, A. A. Herzlich, M. Patel, C.C. Chan: Limbal stem cell deficiency arising from systemic chemotherapy with hydroxycarbamide. Cornea 28:221-223, 2009. PubMed

I.M. MacDonald, L. Russell, C.C. Chan: Choroideremia: New findings from ocular pathology and review of recent literature. Surv Ophthalmol 54:401-407, 2009. PubMed

G. Levy-Clarke, X. Ding, S. Yeh, S. Gangaputra, T. Goodglick, G. Byrnes, R.B. Nussenblatt, C.C. Chan: Recalcitrant granulomatous sclerouveitis in a patient with granulomatous ANCA associated vasculitis. Ocul Immunol Inflamm 17:83-87, 2009. PubMed

C.C. Chan, T.C. Sauer: Ocular imaging in primary retinal lymphoma. Am J Ophthalmol 147:764-765, 2009. PubMed

X. Cao, R.J. Bishop, F. Forooghian, Y. Cho, R.N. Fariss, C.C. Chan: Autoimmune retinopathy in systemic lupus erythematosus: Histopathologic features. Open Ophthalmol J 3:15-19, 2009. PubMed

J. Tuo, R.J. Ross, A.A. Herzlich, D. Shen, X. Ding, M. Zhou, S.L. Coon, N. Hussein, N. Salem, Jr., C.C. Chan: A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am J Pathol 175:799-807, 2009. PubMed

S.E. Coupland, C.C. Chan, J.R. Smith: Pathophysiology of retinal lymphoma. Ocul Immunol Inflamm 17:227-237, 2009. PubMed

L.J. Faia, C.C. Chan: Primary intraocular lymphoma. Arch Pathol Lab Med 133:1228-1232, 2009. PubMed

A.R. Djalilian, J.Y. Kim, H.N. Saeed, E.J. Holland, C.C. Chan: Histopathology and treatment of corneal disease in keratitis, ichthyosis, and deafness (KID) syndrome. Eye 24:738-740, 2010. PubMed

A.A. Herzlich, X. Ding, D. Shen, R.J. Ross, J. Tuo, C.C. Chan: Peroxisome proliferator-activated receptor expression in murine models and humans with age-related macular degeneration. Open Biol J 2:141-148, 2009. PubMed

A. Lu, L. Ng, M. Ma, B. Kefas, T.F. Davies, Z. Hernandez, C.C. Chan, D. Forredest: Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. Endocrinology 150:1536-1544, 2009. PubMed

X. Ding, M. Patel, A.A. Herzlich, P.C. Sieving, C.C. Chan: Ophthalmic pathology of Nance-Horan syndrome: Case report and review of the literature. Ophthalmic Genet 30:127-175, 2009. PubMed

X. Ding, M. Patel, D. Shen, A.A. Herzlich, X. Cao, R. Villasmil, K. Klupsch, J. Tuo, J. Downward, C.C. Chan: Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Invest Ophthalmol Vis Sci 50:4957-4966, 2009. PubMed

C.C. Chan, S. Fisson, B. Bodaghi: The future of primary intraocular lymphoma (retinal lymphoma). Ocul Immunol Inflamm 17;375-379, 2009. PubMed

Y. Cho, J.J. Wang, E.Y. Chew, F.L. Ferris, III, P. Mitchell, C.C. Chan, J. Tuo: Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci 50:5614-5618, 2009. PubMed

T.C. Sauer, S.M. Meyers, D. Shen, S. Vegh, C. Vygantas, C.C. Chan: Primary intraocular (retinal) lymphoma following ocular toxoplasmosis. Retina Cases Brief Reports 4:160-163, 2010. PubMed

Y. Cho, F.R. Rickles, L.M. Parver, J. Tuo, C.C. Chan: The potential pathophysiological role of tissue factor in age-related macular degeneration. Exp Rev Ophthalmol 5:27-34, 2010.

S. Yeh, E.D. Weichel, L.J. Faia, T.A. Albini, K.K. Wroblewski, M. Stetler-Stevenson, P. Ruiz, H.N. Sen, C.C. Chan, R.B. Nussenblatt: 25-gauge transconjuctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. Br J Ophthalmol 94:633-638, 2010. PubMed

X. Cao, M. Liu, J. Tuo, D. Shen, C.C. Chan: The effect of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res 91:15-25, 2010. PubMed

J. Tang, M.B. Rivers, A.A. Moshfeghi, H.W. Flynn, C.C. Chan: Pathology of Macular Foveoschisis Associated with Degenerative Myopia. J Ophthalmol 2010:1-4, 2010. PubMed

E. Furusato, J.D. Cameron, C.C. Chan: Evolution of cellular inclusions in Bietti’s crystalline dystrophy. Ophthalmol Eye Dis 2:9-15, 2010. PubMed

C.C. Chan: Couching for cataracts in China. Surv Ophthalmol 55:393-398, 2010. PubMed

M.M. Liu, J. Tuo, C.C. Chan: Gene therapy for ocular diseases. Br J Ophthalmol 95:604-612, 2011. PubMed

C.C. Chan, M.M. Liu, J.C. Tsai: The first Western style hospital in China. Arch Ophthalmol 129:791-797, 2011. PubMed

Y. Cho, X. Cao, D. Shen, J. Tuo, L.M. Parver, F.R. Rickles, C.C. Chan: Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Invest 91:591-526, 2011. PubMed

M.M. Liu, E. Furusato, X. Cao, D. Shen, C.C. Chan: Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1 (HTLV-1). Rare Tumors 2:e63;179-182, 2010. PubMed

D. Shen, X. Cao, L. Zhao, J. Tuo, W.T. Wong, C.C. Chan: Naloxone ameliorates retinal lesions in Ccl2/Cx3cr1 double deficient mice via modulation of microglia. Invest Ophthalmol Vis Sci 52:2897-2904, 2011. PubMed

E. Furusato, D. Shen, X. Cao, B. Furusato, R.B. Nussenblatt, E.J. Rushing, C.C. Chan: Inflammatory cytokine and chemokine expression in sympathetic ophthalmia. Histol Histopathol 26:1145-1151, 2011. PubMed

M.M. Liu, E. Agron, E.Y. Chew, C.B. Melerle, F.L. Ferris, III, C.C. Chan, J. Tuo: Copy number variation in candidate genes in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 52:3129-3135, 2011. PubMed

J. Tuo, J.J. Pang, X. Cao, D. Shen, J. Zhang, A. Scaria, S.C. Wadsworth, P. Pechan, S.L. Boye, W.W. Hauswirth, C.C. Chan: AAV-5 mediated sFLT01 gene therapy arrests retinal lesions in Ccl2-/-/Cx3cr1-/- mice. Neurobiol Aging 33:433.e431-433.e410, 2011. PubMed

H.L. Ramkumar, B.P. Brooks, X. Cao, D. Tamura, J.J. DiGiovanna, K.H. Kraemer, C.C. Chan: Ophthalmic manifestations and histopathology of xeroderma pigmentosum: Two clinicopathological cases and review of the literature. Surv Ophthalmol 56:348-361, 2011. PubMed

D.N. Hu, M. Chen, D.Y. Zhang, F. Ye, S.A. McCormick, C.C. Chan: Interleukin-1β increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via p38 MAPK/NF-κB pathway. Invest Ophthalmol Vis Sci 52:3767-3774, 2011. PubMed

X. Cao, R. Ursea, D. Shen, H.L. Ramkumar, C.C. Chan: Aberrant fibrosis induced by an intrastromal corneal ring: a case report. J Med Case Rep 5:398, 2011. PubMed

X. Cao, D. Shen, M.M. Patel, J. Tuo, T.M. Johnson, T.W. Olsen, C.C. Chan: Macrophage polarization in the maculare of age-related macular degeneration: a pilot study. Pathol Int 61:528-535, 2011. PubMed

F. Forooghian, A.B. Merkur, V. White, D. Shen, C.C. Chan: High-definition optical coherence tomography features of primary vitreoretinal lymphoma. Ophthal Surg Las Im 42:e97-99, 2011. PubMed

D. Ardeljan, J. Tuo, C.C. Chan: Carboxyethylpyrrole plasma biomarkers in age-related macular degeneration. Drug Future 36:713-718, 2011.

Y. Wang, D. Shen, V.M. Wang, H.N. Sen, C.C. Chan: Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma. Int J Mol Sci 12:5684-5697, 2011. PubMed

C.C. Chan, J.L. Rubenstwin, S.E. Coupland, J.L. Davis, J.W. Harbour, P.B. Johnston, N. Cassoux, V. Touitou, J.R. Smith, T.T. Batchelor, J.S. Pulido: Primary vitreoretinal lymphoma: A report from an international primary central nervous system lymphoma collaborative group symposium. The Oncologist 16:1589-1599, 2011. PubMed

J. Tuo, S. Grob, K. Zhang, C.C. Chan: Genetics of immunological and inflammatory components in age-related macular degeneration. Ocul Immunol Inflamm 20:27-36, 2012. PubMed

J. Tuo, X. Cao, D. Shen, Y. Wang, J. Zhang, J.Y. Oh, D.J. Prockop, C.C. Chan: Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model. J Neuroinflamm 9:59, 2012. PubMed

S. Park, C.C. Chan: Von Hippel-Lindau disease (VHL): A need for a murine model with retinal hemangioblastoma. Histol Histopathol 27:975-984, 2012. PubMed

M.E. Aronow, G. Adamus, M. Abu-Asab, Y. Wang, C.C. Chan, A.D. Singh: Paraneoplastic vitelliform retinopathy: Clinicopathologic correlation and review of the literature. Surv Ophthalmol 57:558-564, 2012. PubMed

M.J. Mattapalli, E.F. Wawrousek, C.C. Chan, H. Zhao, J.Roychoudhury, T.A. Ferguson, R.R. Caspi: The rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 53:2921-2927, 2012. PubMed

H.L. Ramkumar, D.F. Shen, J. Tuo, R.M. Braziel, S.E. Coupland, J.R. Smith, C.C. Chan: IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphoma. Graefe's Arch Clin Exp Ophthalmol 250:1541-1548, 2012. PubMed

N. Nagarkatti-Gude, Y. Wang, M.J. Ali, S.G. Honavar, M.J. Jager, C.C. Chan: Genetics of primary intraocular tumors. Ocul Immunol Inflamm 20:244-254, 2012. PubMed

B. Liu, C.C. Chan, R.B. Nussenblatt: Application of Small Molecules/Macromolecules in Ocular Inflammatory Diseases. Anti-inflamm Anti-allergy Agents Med Chem 11:113-120, 2012. PubMed

Y. Wang, D. Shen, V.M. Wang, C.R. Yu, R.X. Wang, J. Tuo, C.C. Chan: Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress. Apoptosis 17:1144-1155, 2012. PubMed

M.M. Liu, C.C. Chan, J. Tuo: Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Hum Genomics 6:13, 2012. PubMed

V.M. Wang, R.B. Rosen, C.B. Meyerle, S.K. Kurup, D. Ardeljan, E. Agron, K. Tai, M. Pomykala, E.Y. Chew, C.C. Chan, J. Tuo: Suggestive association between PLA2G12A SNP rs2285714 and response to anti-VEGF therapy in patients with exudative age-related macular degeneration. Mol Vis 18:2578-2585, 2012. PubMed

X.K. Chu, J. Tuo, C.C. Chan: Genetics of AMD: application to drug design. Future Med Chem 5:13-15, 2013. PubMed

Y. Wang, M.S. Abu-Asab, W. Li, M.E. Aronow, A.D. Singh, C.C. Chan: Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy. BMC Ophthalmol 12:56, 2012. PubMed

L. Wei, B. Liu, J. Tuo, D. Shen, P. Chen, Z. Li, X. Liu, J. Ni, P. Dagur, H.N. Sen, S. Jawad, D. Ling, S. Park, S. Chakrabarty, C. Meyerle, E. Agron, F.L. Ferris 3rd, E.Y. Chew, J.P. McCoy, E. Blum, P.J. Francis, M.L. Klein, R.H. Guymer, P.N. Baird, C.C. Chan, R.B. Nussenblatt: Hypomethylation of IL17RC promoter associates with age-related macular degeneration. Cell Report 2:1151-1158, 2012. PubMed

X.K. Chu, Y. Wang, D. Ardeljan, J. Tuo, C.C. Chan: Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengineered 4(3), 2012. PubMed

Supplemental Materials

C.C. Chan, J.A. Gonzales: Primary Intraocular Lymphoma. World Scientific Publishing Co., Singapore, London, Hackensack NJ, 2007. World Scientific

C. Cukras, C.C. Chan: Chapter IV. Diagnosis and treatment of retinitis pigmentosa based on the pathology. In Retinitis Pigmentosa: Causes, diagnosis and treatment. Nova Science Publisher, Hauppauge, NY 2010; pp.111-125. Nova Science Pub

H.E. Wiley, C.C. Chan: Chapter 1. Correlation of phenotype and genotype in age-related macular degeneration. In Macular degeneration: Causes, Diagnosis and Treatment. E.J. Campbell, L.M. McMarnn (eds). Nova Science Publisher, Hauppauge, NY 2011; pp. 1-28. Nova Science Pub

T.A. Larson, H.N. Sen, C.C. Chan: Chapter VI. Clinical and immunological highlights of non-infectious uveitis. In Advances in Eye Research. Volume 1. Nova Science Pulbisher, Hauppauge, NY 2011; pp. 131-146. Nova Science Pub

Last Reviewed: January 2013