Immunopathology Section

Recent Publications

Selected Review Articles

C.C. Chan, Q. Li: Immunopathology of uveitis. Br J Ophthalmol 82:91-96, 1998. PubMed

G. Adamus, C.C. Chan: Experimental autoimmune uveitides: Multiple antigens, diverse diseases. In Caspi, R.R. (ed.): The eye: Immunity and autoimmunity. Int Rev Immunol 21:209-229, 2002. PubMed

C.C. Chan, D.F. Shen: Newer methodologies in immunohistochemistry and diagnosis. In D. BenEzra (ed): Uveitis Update. In Dev. Ophthalmol. Karger, Basel, Switzerland, 1999;31: pp.1-13. PubMed

C.C. Chan: Molecular pathology of primary intraocular lymphoma. Tranas Am Ophthalmol Soc 101:269-286, 2003. PubMed

C.C. Chan, D.J. Wallace: Intraocular lymphoma: Update on diagnosis and management. Cancer Control 11:285-295, 2004. PubMed

J. Tuo, C.M. Bojanowski, C.C. Chan: Genetic factors of age-related macular degeneration. Prog Ret Eye Res 23:229-249, 2004. PubMed

R.J. Ross, V. Verma, K.I. Rosenberg, C.C. Chan, J. Tuo: Genetic markers and biomarkers for age-related macular degeneration. Future Drugs-Expert Rev Ophthalmol 2:443-457, 2007. PubMed

Peer Reviewed Journal Articles

H.N. Sen, C.C. Chan, R.C. Caruso, R. Fariss, R.B. Nussenblatt, R.R. Buggage: Waldenstrom macroglobulinemia-associated retinopathy. Ophthalmology 111:535-539, 2004. PubMed

K. Csaky, J. Buffi, C.C. Chan, G.A. Byrnes: Clinicopathologic correlation of progressive fibrovascular proliferation associated with occult choroidal neovascularization in age-related macular degeneration. Arch Ophthalmol 122:650-652, 2004. PubMed

L. Al-Attar, A. Berrocal, R. Warman, S. Dubovy, A. Paredes, C.C. Chan, J. Davis: diagnosis by polymerase chain reaction of ocular post-transplant lymphoproliferative disorder after pediatric renal transplantation. Am J Ophthalmol 137:569-571, 2004. PubMed

M. Yokota, H. Takase, Y. Imai, K. Kamoi, S. Sugita, H. Morita, T. Takizawa, S. Tanaka, D.F. Shen, C.C. Chan, M. Mochizuki: A case of intraocular malignant lymphoma diagnosed by immunoglobulin gene rearrangement and translocation, and IL-10/IL-6 ratio in the vitreous fluid. Jpn J Ophthalmol 47:625, 2003. PubMed

S.W. McPherson, J. Ying, C.C. Chan, C. Dou, D.S. Gregerson: Recognition of B-galactosidase expressed in immune privileged retina by resting and activated CD8 T cells. Immunology 110:386-396, 2003. PubMed

J. Tuo, C.M. Bojanowski, C.C. Chan: Genetic factors of age-related macular degeneration. Prog Ret Eye Res 23:229-249, 2004. PubMed

M. Miyanaga, M. Kiyosawa, H. Takase, Y. Eishi, D.F. Shen, C.C. Chan, M. Mochizuki: Microdissection and gene rearrangement analysis of paraffin-embedded specimens of orbital malignant lymphoma. Jpn J Ophthalmol 48:123-127, 2004. PubMed

S.S. Lee, M.R. Robinson, J.C. Morris, B.C. Mirtsching, D.F. Shen, C.C. Chan: Conjunctival involvement with T-cell prolymorphocytic leukemia: Report of a case and review of the literature. Surv Ophthalmol 49:525-536, 2004. PubMed

J. Tuo, N. Tuaillon, D.F. Shen, C.C. Chan: Endotoxin-induced uveitis in cyclooxygenase 2 deficient mice. Invest Ophthalmol Vis Sci 45:2306-2313, 2004. PubMed

H.N. Sen, C.C. Chan, R.B. Nussenblatt, R.R. Buggage: Occult primary carcinoma metastatic to the iris. Acta Ophthalmol Scand 82:146-147, 2004. PubMed

E.K. Akpek, C.C. Chan, W.R. Green: Lack of viral etiology in serpiginous choroiditis. Ophthalmology 111:2071-2075, 2004. PubMed

E.T. Tsilou, C.C. Chan, F. Sandrini, B.I. Rubin, D. Shen, J.A. Camey, M. Kaiser-Kupfer, C.A. Stratakis: Eyelid myxoma in Carney complex without PRKAR1A allelic loss. Am J Med Genet 130A:395-397, 2004. PubMed

W.K. Lim, S.P. Chee, I. Sng, R. B. Nussenblatt, C.C. Chan: Immunopathology of progressive subretinal fibrosis - A variant of sympathetic ophthalmia. Am J Ophthalmol 138:475-477, 2004. PubMed

C.C. Chan, D.J. Wallace: Intraocular lymphoma: Update on diagnosis and management. Cancer Control 11:285-295, 2004. PubMed

B.J. Kim, Z. Li, R.N. Fariss, D.F. Shen, M.P. Sankaranarayana, C. Egwuagu, C.R. Yu, C.N. Nagineni, C.C. Chan, R.B. Nussenblatt: Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors. Invest Ophthalmol Vis Sci 45:3170-3175, 2004. PubMed

C.C. Chan, J.A. Smith, D. Shen, R. Ursea, P. LeHoang, H.E. Grossniklaus: Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma. Histol Histopathol 19:1219-1226, 2004. PubMed

J. Tuo, B. Smith, C.M. Bojanowski, A.D. Meleth, I. Gery, K. Csaky, E.Y. Chew, C.C. Chan: The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J 18:1297-1299, 2004 (FASEB J express article on line, 6/18/2004). PubMed

R.B. Buggage, B. Myers-Powell, J.M. McManaway, D.Shen, M.R. Robinson, C.C. Chan: Detection of the Philadelphia chromosome in the iris of a child with acute lymphoblastic leukemia (ALL). Histopathology 46:350-352, 2005. PubMed

C.C. Chan, G.F. Reed, Y. Kim, E. Agrón, R.R. Buggage: A correlation of pregnancy term, disease activity, serum female hormones and cytokines in uveitis. Br J Ophthalmol 88:1506-1509, 2004. PubMed

C.C. Chan, Y.S. Lee, Z. Zhuang, J. Hackett, E.Y. Chew: von Hippel-Lindau (VHL) gene deletion and expression of hypoxia-inducible factor and ubiquitin in optic nerve hemangioma. Trans Am Ophthalmol Soc 102:75-81, 2004. PubMed

W.K. Lim, R.B. Nussenblatt, C.C. Chan: Immunopathology of inflammatory Coats disease. Arch Ophthalmol 123:279-281, 2005. PubMed

R. Mathur, W.K. Lim, C.C. Chan, S.P. Chee: Reactive iris lymphoid proliferation presenting as the AIDS defining event in an HIV patient with systemic lymphoma. AIDS 18:2215-2216, 2004. PubMed

S. Jardeleza, C.C. Chan, I. Shalaby, Z. Dela Cruz, D.F. Shen, W.R. Green: Clinicopathologica and ultrastructural study of endogenous Klebsiella pneumoniae endophthalmitis. Retina 25:657-662, 2005. PubMed

M.R. Robinson, C.C. Chan, J.C. Yang, B.I. Rubin, G.J. Gracia, H.N. Sen, K.G. Csaky, S.A. Rosenberg: Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: A new cause of uveitis. J Immunotherapy 27:478-479, 2004. PubMed

C.C. Chan, D.F. Shen, J. Tuo: Polymerase chain reaction in the diagnosis of uveitis. Int Ophthalmol Clin 45:41-55, 2005. PubMed

S.K. Kim, C.C. Chan, D.J. Wallace: Management of primary intraocular lymphoma. Curr Oncol Rep 7:74-79, 2005. PubMed

S.K. Kurup, H. Coleman, C.C. Chan: Corneal pseudomembrane from acute inflammatory response and fibrin formation to acute myeloid leukemic infiltrate. Am J Ophthalmol 139:921-923, 2005. PubMed

A.M. Mansour, C.C. Chan, M.A. Crawford, Z.A. Tabbara, D. Shen, W.F. Haddad, H.I. Salti, N.G. Ghazi: Virus-induced chalazion. Eye online, March 4, 2005. PubMed

C.C. Chan, M. Fischette, D.F. Shen, S.P. Mahesh, R.B. Nussenblatt, J. Hochman: Murine model of primary intraocular lymphoma. Invest Ophthalmol Vis Sci 46:415-419, 2005. PubMed

S.K. Srivastava, D.F. Martin, S.D. Mellow, D.J. Parks, K. Dastgheib, C.C. Chan: Pathological findings in eyes with the ganciclovir implant. Ophthalmology 112:780-788, 2005. PubMed

A.R. Djalilian, S.P. Mahesh, C.A. Koch, R.B. Nussenblatt, D.F. Shen, Z. Zhuang, E.J. Holland, C.C. Chan: Survival of donor epithelial cells after limbal stem cell transplantation. Invest Ophthalmol Vis Sci 46:803-807, 2005. PubMed

L. Kercher, C. Favara, C.C. Chan, R. Race, B. Chesebro: Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. Am J Pathol 165:2055-2067, 2004. PubMed

L. Schopf, S. Luccioli, V. Bundoc, P. Justice, C.C. Chan, B.J. Wetzel, H.H. Norris, J.F. Urban, Jr., A. Keane-Myers: Differential modulation of allergic eye disease by chronic and acute Ascaris infection. Invest Ophthalmol Vis Sci 46:2772-2780, 2005. PubMed

P.A. Antony, C.A. Piccirillo, A. Akpinarli, S.E. Finkelstein, P.J. Speiss, D.R. Surman, D.C. Palmer, C.C. Chan, C.A. Klebanoff, W.W. Overwijk, S.A. Rosenberg, and N.P. Restifo: CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174:2591-2601, 2005. PubMed

W.K. Lim, R. Ursea, S.E. Straus, C.C. Chan, R.B. Nussenblatt: Bilateral uveitis in a patient with autoimmune lymphoproliferative syndrome. Am J Ophthalmol 139:562-563, 2005. PubMed

C.Y. Cui, J.A. Smith, D. Schlessinger, C.C. Chan: X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol 167:89-95, 2005. PubMed

C.C. Chan, M. Zhang: Ocular manifestations in HIV/AIDS. Chin J Ophthalmol 41:563-571, 2005. PubMed

C.C. Chan, J. Tuo, C.M. Bojanowski, K.G. Csaky, R.W. Green: Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histol Histopathol 20:857-863, 2005. PubMed

D.J. Wallace, C.R. Altemare, D.F. Shen, M.D. deSmet, R.R. Buggage, R.B. Nussenblatt, C.C. Chan: Primary testicular and intraocular lymphomas: Two case reports and a review of the literature. Surv Ophthalmol 51:41-50, 2006. PubMed

G.A. Levy-Clarke, C.C. Chan, R.B. Nussenblatt: Diagnosis and Management of primary intraocular lymphoma. Hematol/Oncol Clin Nor Am 19:739-749, 2005. PubMed

A.D. Meleth, E. Agrón, C.C. Chan, G.F. Reed, K. Arora, G. Byrnes, K.G. Csaky, F.L. Ferris, III, E.Y. Chew: Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci 46:4295-4301, 2005. PubMed

S.K. Kurup, C.C. Chan: Immunotherapeutic approaches in ocular inflammatory diseases: a review. Arch Immunol Ther Exp 53:484-496, 2005. PubMed

C.C. Chan, E.Y. Chew, D. Shen, J. Hackett, Z. Zhuang: Expression of Stem Cellular Markers in Ocular Hemangioblastoma Associated with von Hippel-Lindau Disease (VHL). Mol Vis 11:697-704, 2005. PubMed

J.H. Tsai, J.M. Freeman, C.C. Chan, G.S. Swartz, E.A. Derby, E.J. Holland: A progressive anterior fibrosis syndrome in post-surgical congenital aniridia patients. Am J Ophthalmol 140:1075-1079, 2005. PubMed

M. Zhou, G. Xu, C.M. Bojanowski, Y Song, R. Chen, X. Sun, W. Wang, C.C. Chan: Differential diagnosis of anterior chamber cysts with ultrasound biomicroscopy: Ciliary body medulloepithelioma. Acta Ophthalmol Scand 84:137-139, 2006. PubMed

H. Kim, K.G. Csaky, C.C. Chan, P.M. Bungay, R.J. Lutz, R.L. Dedrick, P. Yuan, J. Rosenberg, A.J. Grillo-Lopez, W.H. Wilson, M.R. Robinson: The pharmacokinetics of rituximab following an intraocular injection. Exp Eye Res 82:760-766, 2006. PubMed

D. Shen, R. Wen, J. Tuo, C.M. Bojanowski, C.C. Chan: Exacerbation of Retinal Degeneration and Choroidal Neovascularization Induced by Subretinal Injection of Matrigel in CCL2/MCP-1 Deficient Mice. Ophthalmic Res 38:71-73, 2006. PubMed

R.R. Buggage, R.M. Bauer II, S.M. Holland, C.I. Santos, C.C. Chan: Uveitis and a subretinal mass in a patient with chronic granulomatous disease. Br J Ophthalmol 90:514-515, 2006. PubMed

S.K. Kurup, C.C. Chan: Mycobacterium related ocular inflammatory disease: Diagnosis and management. Ann Acad Med Singapore 35:203-207, 2006. PubMed

J. Tuo, B. Ning, C.M. Bojanowski, Z.N. Lin, R.J. Ross, G.F. Reed, D. Shen, X. Jiao, M. Zhou, E.Y. Chew, F.F. Kadlubar, C.C. Chan: Synergic effect of polymorshisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. P Natl Acad Sci USA 103:9256-9261, 2006. PubMed

D.F. Shen, H.K.L. Yuen, D.A. Galita, N.R. Chan, C.C. Chan: Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue (MALT) lymphoma. Am J Ophthalmol 141:1162-1163, 2006. PubMed

R.B. Nussenblatt, C.C. Chan, W.H. Wilson, J. Hochman, M. Gottesman for the Ocular Lymphoma Workshop Group: International central nervous system and ocular lymphoma workshop: Recommendations for the future. Ocul Immunol Inflam 14:139-144, 2006. PubMed

M. Zhou, L. Gradstein, J.A. Gonzales, E.T. Tsilou, W.A. Gahl, C.C. Chan: Ocular pathology of Hermansky-Pudlak syndrome type 1 in an adult. Arch Ophthalmol 124:1048-1051, 2006. PubMed

D.J. Wallace, D. Shen, G.F. Reed, M. Miyanaga, M. Mochizuki, H.N. Sen, S.S. Dahr, R.R. Buggage, R.B. Nussenblatt, C.C. Chan: Detection of the bcl-2 t(14;18) translocation and proto-oncogen expression in primary intraocular lymphoma. Invest Ophthalmol Vis Sci 47:2750-2756, 2006. PubMed

C.C. Chan, D. Shen, M. Mochizuki, H.K.L. Yuen, J.A. Gonzales, Y. Guex-Crosier, P. LeHoang: Detection of Helicobacter pylori (H. pylori) and Chlamydia pneumoniae (C. pneumoniae) genes in primary orbital lymphoma. Trans Am Ophthalmol Soc 104:62-70, 2006. PubMed

E. Tsilou, M. Zhou, W. Gahl, P.C. Sieving, C.C. Chan: Ophthalmic manifestations and histopathology of infantile nephropathic cystinosis: Report of a case and review of the literature. Surv Ophthalmol 52:97-105, 2007. PubMed

C.M. Bojanowski, D. Shen, E.Y. Chew, B. Ning, K.G. Csaky, W.R. Green, C.C. Chan, J. Tuo: An Apolipoprotein E varient may protect against age-related macular degeneration through cytokine regulation. Enviro Mol Mutagen 47:594-602, 2006. PubMed

X. Liang, D. Shen, Y. Huang, C. Yin, C.M. Bojanowski, Z. Zhuang, C.C. Chan: Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease. Ophthalmology 114:147-56, 2007 PubMed

C.C. Chan, A.B.D. Collins, E.Y. Chew: Molecular pathology of the eyes with von Hippel-Lindau (VHL) disease: A review. Retina 27:1-7, 2007. PubMed

Z. Li, S.P. Mahesh, D.F. Shen, B. Liu, W.O. Siu, F.S. Hwang, Q.C. Wang, C.C. Chan, I. Pastan, R.B. Nussenblatt: Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. Cancer Res 66:10586-10593, 2006. PubMed

R.J. Ross, C.M. Bojanowski, J.J. Wang, E.Y. Chew, E. Rochtchina, F.L. Ferris, III, P. Mitchell, C.C. Chan, J. Tuo: The LOC38775 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci 48:1128-1132, 2007. PubMed

N. Cassoux, A. Giron, B. Bodaghi, T.H.C. Tran, S. Baudet, F. Davy, C.C. Chan, P. LeHoang, H. Merle-Beral: IL-10 measurement in aqueous humor for screening patients with suspecion of primary intraocular lymphoma (PIOL). Invest Ophthalmol Vis Sci 48:3253-3259, 2007. PubMed

M. Shah, E.J. Holland, C.C. Chan: Resolution of autoimmune polyglandular syndrome associated keratopathy with keratolimbal stem cell transplantation: Case report and historical literature review. Cornea 26:632-635, 2007 PubMed

J.A. Gonzales, C.C. Chan: Biopsy techniques and yields in diagnosing primary intraocular lymphoma. Int Ophthalmol 27:241-250, 2007. PubMed

S.K. Kurup, G. Levy-Clarke, K.R. Calvo, E.S. Jaffe, R.B. Nussenblatt, C.C. Chan: Primary diffuse large B cell lymphoma of the spleen with coincident serous retinal detachment responsive to corticosteroids. Clin Experiment Ophthalmol 35:468-472, 2007. PubMed

J. Tuo, C.M. Bojanowski, M. Zhou, D. Shen, R.J. Ross, K.I. Rosenberg, D. J. Cameron, C. Yin, J.A. Kowalak, Z. Zhuang, K. Zhang, C.C. Chan: Murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 48:3827-3836, 2007. PubMed

Supplemental Materials

J. Tuo, C.M. Bojanowski, C.C. Chan: Recent research developments in age-related macular degeneration genetics. In Recent Research Developments In Ophthalmology. S.G. Pandalai (ed); Transworld Research Network, Trivandrum, India, 2004; 1:13-24.

C.C. Chan, R.B. Nussenblatt: Ocular inflammation and neovascularization. In Ocular Angiogenesis: Disease, Mechanism, and Therapeutics. J. Tombran-Tink, C.J. Barnstable (eds); Human Press Inc., Totowa, NJ, 2006; pp. 291-305.

C.C. Chan: Clinicians' corner questions for Focal Points title: "Primary intraocular lymphoma" American Academy of Ophthalmology Vol. 58, No. 12, 2005.

J.J. Hooks, M.S. Chin, C.C. Chan, B. Detrick: Chapter 129. Monitoring autoimmune reactivity within the retina. In Manual of Molecular and Clinical Laboratory Immunology. B. Detrick, R. Hamilton, T. Folds (eds); ASM Press, Washington, D.C., 2006; pp. 1136-1140.

C.C. Chan, J.A. Gonzales: Primary Intraocular Lymphoma. World Scientific Publishing Co. Singapore, London, Hackensack NJ, 2007.