Primary intraocular lymphoma (PIOL) is a subset of primary CNS lymphoma. PIOL is mostly a diffuse large B cell non-Hodgkin's lymphoma that usually invades the retina, vitreous, or optic nerve with or without concomitant CNS involvement. Majority of PIOL is a diffuse large B cell lymphoma. Although it is a rare disease, PIOL is fatal and the incidence has increased in the past two decades. Our main interests are diagnosis, molecular pathology and pathogenesis of the malignancy.

Fundus photo showing primary intraocular lymphoma
Photomicrograph slide showing lymphoma between retinal and choroid