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Home » NEI Laboratories » Laboratory of Sensorimotor Research » Neuronal Networks » Okihide Hikosaka, M.D., Ph.D.

Okihide Hikosaka, M.D., Ph.D.

Curriculum Vitae

Publications

Original Papers

See Article Depository

Reviews

Bromberg-Martin ES, Matsumoto M, Hikosaka O (2010) Dopamine in motivational control: rewarding, aversive, and alerting. Neuron 68:815-834.

Hikosaka O (2010) The habenula: from stress evasion to value-based decision-making. Nat Rev Neurosci 11:503-513.

Hikosaka O, Isoda M (2010) Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms. Trends Cogn Sci 14: 154-161.

Hikosaka O, Sesack SR, Lecourtier L, Shepard PD (2008) Habenula: crossroad between the basal ganglia and the limbic system. J Neurosci 28:11825-11829.

Hikosaka O, Bromberg-Martin E, Hong S, Matsumoto M (2008) New insights on the subcortical representation of reward. Curr Opin Neurobiol 18:203-208.

Hikosaka O (2008) [Decision-making and learning by cortico-basal ganglia network]. Brain Nerve 60:799-813.

Balleine BW, Delgado MR, Hikosaka O (2007) The role of the dorsal striatum in reward and decision-making. J Neurosci 27:8161-8165.

Hikosaka O (2007) Basal Ganglia Mechanisms of Reward-oriented Eye Movement. Ann N Y Acad Sci 1104:229-249.

Hikosaka O (2007) Habenula. Scholarpedia 2:2703. http://www.scholarpedia.org/article/Habenula

Hikosaka O (2007) GABAergic output of the basal ganglia. Prog Brain Res 160:209-226.

Hikosaka O, Nakamura K, Nakahara H (2006) Basal Ganglia orient eyes to reward. J Neurophysiol 95:567-584.

Sakai K, Hikosaka O, Nakamura K (2004) Emergence of rhythm during motor learning. Trends Cogn Sci 8:547-553.

Donoghue JP, Hikosaka O (2003) Motor systems. Curr Opin Neurobiol 13:643-646.

Hikosaka O (2002) A new approach to the functional systems of the brain. Epilepsia 43 Suppl 9:9-15.

Hikosaka O, Nakamura K, Sakai K, Nakahara H (2002) Central mechanisms of motor skill learning. Curr Opin Neurobiol 12: 217–222.

Hikosaka O, Takikawa Y, Kawagoe R (2000) Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol. Rev. 80: 953-978.

Hikosaka O, Sakai K, Nakahara H, Lu X, Miyachi S, Nakamura K, Rand MK (1999) Neural mechanisms for learning of sequential procedures. In: The New Cognitive Neurosciences (Gazzaniga MS, eds), pp. 553-572, Cambridge, MA: The MIT Press.

Hikosaka O, Nakahara H, Rand MK, Sakai K, Lu X, Nakamura K, Miyachi S, Doya K (1999) Parallel neural networks for learning sequential procedures. Trends Neurosci 22: 464-471.

Hikosaka O (1999) Probing consciousness with an electrode. Brain Res Bull 50: 337-338.

Hikosaka O (1998b) Neural systems for control of voluntary action - a hypothesis. Advances in Biophysics 35: 81-102.

Hikosaka O, Miyashita K, Miyachi S, Sakai K, Lu X (1998) Differential roles of the frontal cortex, basal ganglia, and cerebellum in visuomotor sequence learning. Neurobiology of Learning and Memory 70: 137-149.

Hikosaka O, Miyauchi S, Shimojo S (1996e) Orienting of spatial attention - its reflexive, compensatory, and voluntary mechanisms. Cognitive Brain Research 5: 1-9.

Hikosaka O, Miyauchi S, Takeichi H, Shimojo S (1996f) Multimodal spatial attention visualized by motion illusion. In: Attention and Performance XVI : Information Integration in Perception and Communication (Inui T, McClelland J, eds), pp. 237-261. Cambridge, MA: MIT Press.

Hikosaka O, Miyauchi S, Shimojo S (1993d) Visual attention revealed by an illusion of motion. Neurosci Res 18: 11-18.

Hikosaka O (1991a) Basal ganglia - possible role in motor coordination and learning. Curr Opin Neurobiol 1: 638-643.

Hikosaka O (1989c) Role of basal ganglia in saccades. Rev Neurol (Paris) 145: 580-586.

Evarts EV, Kimura M, Wurtz RH, Hikosaka O (1984) Behavioral correlates of activity in basal ganglia neurons. Trends Neurosci 7: 447-453.

Book sections

Hikosaka O (2009) Basal Ganglia and Oculomotor Control. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 2, pp. 53-61. Oxford: Academic Press.

Nomura Y., Fukuda H., Terao Y., Hikosaka O., Segawa M. (2003) Abnormalities of voluntary saccades in Gilles de la Tourette's syndrome: pathophysiological consideration. Brain Dev 25 Suppl 1: S48-54.

Shimojo S., Hikosaka O., Miyauchi S. (In press) Automatic and controlled processes of attention revealed in the line motion effect. In: Attention & Performance XV (Gopher D, Koirat A, eds), pp. Cambridge, MA: MIT Press.

Hikosaka O., Sakai K., Nakahara H., Lu X., Miyachi S., Nakamura K., Rand M.K. (1999) Neural mechanisms for learning of sequential procedures. In: The Cognitive Neurosciences (Gazzaniga MS, eds), pp. 553-572. Cambridge, MA: The MIT Press.

Hikosaka O., Miyachi S., Miyashita K., Rand M.K. (1996a) Learning of sequential procedures in monkeys. In: The Acquisition of Motor Behavior in Vertebrates (Bloedel JR, Ebner TJ, Wise SP, eds), pp. 303-317. Cambridge, MA: The MIT Press.

Hikosaka O., Miyachi S., Miyashita K., Rand M.K., Karadi Z. (1996b) Procedural learning in monkeys - possible roles of the basal ganglia. In: Perception, Memory, and Emotion: Frontier in Neuroscience (Ono T, McNaughton BL, Molotchnikoff S, Rolls ET, Nishijo H, eds), pp. 403-420. Oxford, UK: Elsevier.

Hikosaka O., Miyachi S., Miyashita K., Sakai K., Miyauchi S., Takino R., Sasaki Y., Pütz B. (1996c) Neural mechanisms of sequential procedural learning. In: Integrative and Molecular Approach to Brain Function (Ito M, Miyashita Y, eds), pp. 285-292. Amsterdam: Elsevier.

Hikosaka O., Miyashita K., Sakai K., Miyauchi S., Takino R., Sasaki Y., Pütz B. (1996d) Role of the medial frontal cortex in sequential procedural learning. In: Brain Processes and Memory (Ishikawa K, McGaugh JL, Sakata H, eds), pp. 299-306. Amsterdam: Elsevier.

Hikosaka O., Rand M.K., Miyashita K., Miyachi S. (1996g) Learning of sequential procedures in monkeys. In: Recent Advances in Clinical Neurophysiology (Kimura J, Shibasaki H, eds), pp. 296-303. Amsterdam: Elsevier.

Hikosaka O., Sakai K., Miyauchi S., Takino R., Sasaki Y., Pütz B. (1996j) Brain activation during learning of sequential procedures. In: Visualization of Information Processing in the Human Brain: Recent Advances in MEG and Functional MRI (Hashimoto I, Okada YC, Ogawa S, eds), pp. 245-252. Amsterdam: Elsevier.

Segawa M., Tanaka R., Nomura Y., Fukuda H., Hikosaka O. (1996) Saccadic eye movements in basal ganglia disorders. In: Recent Advances in Clinical Neurophysiology (Kimura J, Shibasaki H, eds), pp. 170-176. Amsterdam: Elsevier.

Shimojo S., Tanaka Y., Hikosaka O., Miyauchi S. (1996) Vision, attention, and action: Inhibition and facilitation in sensory-motor links revealed by the reaction time and the line motion. In: Attention and Performance XVI : Information Integration in Perception and Communication (Inui T, McClelland J, eds), pp. 597-630. Cambridge, MA: MIT Press.

Hikosaka O. (1995) Neural mechanisms of saccadic eye movement. In: Vertigo, Nausea, tinnitus and Hearing Loss in Central and Peripheral Vestibular Diseases. Proceedings of the XXIInd Annual Meeting of the International Neurootological and Equilibriometric Society. (Claussen C-F, Sakata E, Itoh A, eds), pp. 3-18. Amsterdam: Elsevier.

Hikosaka O., Fukuda H., Segawa M., Nomura Y. (1995a) Voluntary saccades in normal and in dopamine deficient subjects. In: Age-Related Dopamine-Deficient Disorders (Segawa M, Nomura Y, eds), pp. 59-68. Basal: Karger.

Hikosaka O., Rand M.K., Miyachi S,. Miyashita K. (1995c) Procedural learning in the monkey. In: Functions of the Cortico-Basal Ganglia Loop (Kimura M, Graybiel AM, eds), pp. 18-30. Tokyo: Springer.

Kato M., Hikosaka O. (1995) Function of the indirect pathway in the basal ganglia oculomotor system: visuo-oculomotor activities of external pallidum neurons. In: Age-Related Dopamine-Deficient Disorders (Segawa M, Nomura Y, eds), pp. 178-187. Basal: Karger.

Hikosaka O. (1994) Role of basal ganglia in control of innate movements, learned behavior and cognition - a hypothesis. In: The Basal Ganglia IV: New Ideas and Data on Structure and Function (Percheron G, McKenzie JS, Féger J, eds), pp. 589-596. New York: Plenum Press.

Segawa M., Hikosaka O., Fukuda H., Uetake K. (1994) Deficits in saccadic eye movements in basal ganglia disorders. In: The Basal Ganglia IV: New Ideas and Data on Structure and Function (Percheron G, McKenzie JS, Feger J, eds), pp. 525-531. New York: Plenum Press.

Hikosaka O., Matsumura M., Kojima J., Gardiner T.W. (1993b) Role of basal ganglia in initiation and suppression of saccadic eye movements. In: Role of the Cerebellum and Basal Ganglia in Voluntary Movement (Mano N, Hamada I, DeLong MR, eds), pp. 213-219. Amsterdam: Elsevier.

Hikosaka O. (1993) Role of the basal ganglia in motor learning: a hypothesis. In: Brain Mechanisms of Perception and Memory (Ono T, Squire LR, Raichle ME, PerrettD.I., Fukuda M, eds), pp. 497-513. New York: Oxford University Press.

Hikosaka O., Fukuda H., Kato M., Uetake K., Nomura Y., Segawa M. (1993a) Deficits in saccadic eye movements in hereditary progressive dystonia with marked diurnal fluctuation. In: Hereditary Progressive Dystonia with Marked Diurnal Fluctuation (Segawa M, eds), pp. 159-177. Lancs & New York: The Parthenon Publishing Group.

Hikosaka O., Imai H., Segawa M. (1992) Saccadic eye movements in parkinsonism. In: Vestibular and Brain Stem Control of Eye, Head and Body Movements (Shimazu H, Shinoda Y, eds), pp. 405-414. Tokyo: Japan Scientific Society Press.

Hikosaka O. (1991b) Role of the forebrain in oculomotor function. In: Role of the Forebrain in Sensation and Behavior (Holstege G, eds), pp. 101-107. Amsterdam: Elsevier.

Hikosaka O. (1989a) Motor programming in basal ganglia. In: Neural Programming (Ito M, eds), pp. 101-109. Tokyo: Japan Scientific Societies Press.

Hikosaka O. (1989b) Role of basal ganglia in initiation of voluntary movements. In: Dynamic Interactions in Neural Networks: Models and Data (Arbib MA, Amari S, eds), pp. 153-167. New York: Springer-Verlag.

Hikosaka O., Wurtz R.H. (1989) The basal ganglia. In: The Neurobiology of Saccadic Eye Movements (Wurtz RH, Goldberg ME, eds), pp. 257-281. Amsterdam: Elsevier.

Hikosaka O., Segawa M., Imai H. (1987) Voluntary saccadic eye movement: application to analyze basal ganglia disease. In: Highlights in Neuro-Ophthalmology (Ishikawa S, eds), pp. 133-138. Amsterdam: Aeolus Press.

Nomura Y., Segawa M., Soda M., Hikosaka O. (1987) Voluntary saccadic eye movements in basal ganglia disorders. In: Highlights in Neuro-Ophthalmology (Ishikawa S, eds), pp. 139-145. Amsterdam: Aeolus Press.

Segawa M., Nomura Y., Hikosaka O., Soda M., Usui S., Kase M. (1987) Roles of the basal ganglia and related structure in symptoms of dystonia. In: The Basal Ganglia II. Structure and Function-Current Concepts (Carpenter MB, Jayaraman A, eds), pp. 489-504. New York: Plenum.

Wurtz R.H., Hikosaka O. (1986) Role of the basal ganglia in the initiation of saccadic eye movements. In: Progress in Brain Research (Freund H-J, Büttner U, Cohen B, Noth J, eds), pp. 175-190. Amsterdam: Elsevier.

Iwamura Y., Tanaka M., Sakamoto M., Hikosaka O. (1985a) Comparison of the hand and finger representation in areas 3,1, and 2 of the monkey somatosensory cortex. In: Development, Organization, and Processing in Somatosensory Pathways (Rowe M, Willis D, eds), pp. 239-245. New York: Liss Inc.

Hikosaka O., Wurtz R.H. (1981) The role of substantia nigra in the initiation of saccadic eye movements. In: Progress in Oculomotor Research (Fuchs A, Becker W, eds), pp. 145-152. North Holland: Elsevier.

Iwamura Y., Tanaka M., Hikosaka O. (1981) Cortical neuronal mechanisms of tactile perception studied in the conscious monkey. In: Brain Mechanisms of Sensation (Katsuki, Sato M, Norgren R, eds), pp. 61-70. New York: J. Wiley.

Wurtz R.H., Albano J.E., Hikosaka O. (1980) Relation of superior colliculus to the initiation of eye movements. In: Adv. Physiol. Sci. (Szentágothai J, Palkovits M, Hámori J, eds), pp. 251-257.



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