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4th Annual NEI Intramural Research Day
October 31, 2003
8:00 a.m. to 3:30 p.m.
Peripheral expression of a Sequestered Autoantigen by DNA Vaccination Protects from Autoimmune Disease
Rajeev K. Agarwal, Phyllis B. Silver, Shao Bo Su, Chi-Chao Chan, Rachel Caspi.
Lab of Immunology, NEI, NIH, 9000 Rockville Pike, Bethesda, MD 20892.
Subconjuntival Delivery of Pigment Epithelium-derived Factor (PEDF) Protein to the Choroid and Retina
J.Amaral1, R. N. Fariss2, M. Campos2, W. G. Robison, Jr. 2, D. Himmelberg3, H. Kim3R. Lutz3, S.P. Becerra1
1LRCMB and 2LMOD; NEI; 3DBEPS, ORS/OD
CD28-Mediated Stabilization of IL-2 mRNA in Activated T Cell is Independent of HuR Binding to the 3’UTR
Hooman Azmi, Yuko Seko and Jack A. Ragheb Laboratory of Immunology, National Eye Institute, National Institutes of Health
Role of Histidines in Mouse b-Carotene 15,15'-Monooxygenase Activity
Eugenia Batyreva1, Susan Gentleman1, Francis X. Cunningham2, F. Ella Greene3, Nancy J. Miller-Ihli3 and Michael Redmond1
1National Eye Institute, NIH, 6/337, Bethesda, MD 20892-2740, 2Department of Plant Biology, University of Maryland, College Park, Maryland 20742 3FoodComposition Laboratory, USDA, Beltsville, MD 20705
A Study to Investigate the Safety and Efficacy of Daclizumab to Treat the Ocular Complications Related to Behçet's Disease
Ronald R. Buggage1, Darby J. Thompson3, H. Nida Sen1, Roxana. Ursea1, Allison T. Bamji1, Thomas Waldmann2, Robert B. Nussenblatt1
1Laboratory of Immunology, National Eye Institute and 2Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 3The EMMES Corporation, Rockville, MD
Ciliary Neurotrophic Factor (CNTF) Delivered By An Encapsulated Cell-Based Intraocular System: Effect On The Electroretinogram (ERG) And Retinal Histology of Normal Rabbit.
1,3Ronald A. Bush, 1,5Bo Lei, 2Weng Tao, 4Chi¡VChao Chan, 4Terry A. Cox, 1,3,4Paul A. Sieving
1Department of Ophthalmology and Visual Science, Kellogg Eye Center, University of Michigan, Ann Arbor, MI; 2Neurotech USA, Lincoln, RI; 3National Institute of Deafness and Communication Disorders and 4National Eye Institute, NIH, Bethesda, MD; 5Department of Veterinary Medicine and Surgery, College of Veterinary Medicine & Department of Ophthalmology, School of Medicine, University of Missouri-Columbia, MO
Microarray Analysis of AlphaA and AlphaB-Crystallin Knockout Mouse Lenses.
D.A. Carper1, M. John-Aryankalayil1, C.J. Jaworski1, K. Brown2, D.A. Stephan2, E.F. Wawrousek3.
SMT, LMOD, NEI1, Children's National Medical Center, Washington, D.C2, TAGMS, LMDB, NEI3.
Molecular signatures of Helicobacter pylori (H. pylori) in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma
Chi-Chao Chan, Janine A. Smith, DeFen Shen, Roxana Ursea, Phuc LeHoang, Hans E. Grossniklaus
Profound Fluctuations in Expression of the Chemokine Receptor CXCR3 by Inflammation-Inducing Th1 Cells
J. Chen,1 B.P. Vistica,1 D.I. Ham,1 R.N. Fariss,2 W.G. Robison, Jr,2 C.C. Chan,1 E.F. Wawrousek,3 and I. Gery1.
Laboratories of 1Immunology, 2Mechanisms of Ocular Diseases, 3Molecular and Developmental Biology, National Eye Institute
RNA Single Stranded Index: A New Parameter for the Optimal Design of Short Interfering RNA (siRNA) for Gene Silencing
WeiPing Chen1, Wei Zha2, Terry Cox3, Xiujun Zhao1, Paul Russell*1
Laboratory of1 Mechanisms of Ocular Diseases and Division of Epidemiology and Clinical Research3, National Eye Institute, National Institutes of Health, Bethesda, Maryland; Cable & Wireless USA, Reston, Virginia2
Dietary Carotenoids and Risk for Age-related Macular Degeneration
E.Y. Chew, J.P. SanGiovanni, R.D. Speduto, N.Kurinij, F.L. Ferris, and The AREDS Research Group
Autoantibodies in a patient with cone-rod degeneration triggers death of retinal ganglion (RGC-5) cells.
Chin MS1A, Nagineni CN1A, Caruso R1B, Agarwal N2, Detrick B3 and Hooks JJ1A
ALaboratory of Immunology, BOphthalmic Genetics and Visual Function Branch, 1NIH/NEI; 2Department of Pathology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Changes in the Predicted Secondary Structure of Interleukin-s mRNA Associated with Its CD-28 Mediated Stabilization
Cole, Steven,*, 1, 2 Kasprzak, Wojciech,3 Shapiro, Bruce,4 Ragheb, Jack,2
1George Mason University, Fairfax, VA, 2LI, National Eye Institute, NIH, Bethesda, MD, 3BRP, SAIC-Frederick, Inc., 4LECB, National Cancer Institute at Frederick, Frederick, MD
Keratinization in the Conjunctiva of Patients with Keratoconjunctivitus Sicca
M.A. Crawford, .H.C. Humphrey, J.J .Hackett, I.M. Wise, J.A. Smith, C.C. Chan
In vivo Dynamic Light Scattering (DLS) Studies of the Lens and Cornea
Datiles MB1, Ansari RR2, Suh K2, Reed G1, King J.2
1National Eye Institute-NIH, Bethesda, MD, 2 NASA-Glenn Research Center, Cleveland, OH
Postnatal Gene Expression in the Normal Mouse Cornea: A SAGE Analysis
Janine Davis, Barbara Norman, and Joram Piatigorsky.
The Potential for Trans-differntiation of Bone Marrow Stem Cells into Ocular Surface Epithelial Cells
A.R. Djalilian, Q.Y. Fan, J.A. Smith, R.B. Nussenblatt, J.C. Vogel, E.J. Holland, C.C. Chan.
National Eye Institute, National Cancer Institute, National Institute of Health, Bethesda, MD; Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH.
Specific interaction between lens MIP/Aquaporin-0 and gamma-E-crystallin results in gamma-E-crystallin recruitment to the plasma membrane.
J. Fan, A.K. Donovan, D.R. Ledee, P.S. Zelenka, R. Fariss, A.B. Chepelinsky Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Cdk5 Regulates Corneal Epithelial Cell Migration and Peripheral Localization of Active Src during Wound Healing
1C.Y. Gao, 2M.A. Stepp, 1Robert Fariss, and 1P.S. Zelenka,
National Eye Institute, NIH, and 2George Washington University
Effects of Extended Organ Culture on the Rat Lens
Madhumita Ghosh and J. Samuel Zigler, Jr.
Laboratory of Mechanism of Ocular Diseases
The possible role of Protein Kinase C in the trafficking of MIP/Aquaporin 0
Nady Golestaneh, Jianguo Fan, Peggy Zelenka, Robert Fariss and Ana B. Chepelinsky
Laboratory of Molecular and Developmental Biology. National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Eye Movements in Chorea-Acanthocytosis
L.Gradstein1, A.Danek2, J.Grafman3, E.J. FitzGibbon1.
1Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD; 2University Department of Neurology, LMU, Munich, Germany; 3Cognitive Neuroscience Section, NINDS, Bethesda, MD.
Pax-6 as a Possible Regulator of the Optimedin Gene Activity
O. Grinchuk, Z. Kozmik, X. Wu, S. Tomarev. LMDB, NEI, NIH, Bethesda.
Immunohistochemistry and Ultrastructure of Angioma in von Hipple-Lindau Disease
Joseph Hackett, Emily Y. Chew,* Mary Alice Crawford, DeFen Shen, Chi-Chao Chan
Immunopathology, Laboratory of Immunology and *Division of Epidemiology and Clinical Research, National Eye Institute
Elevated TNF-a and soluble TNF Receptor in Degeneration Susceptible Mice with Experimental Coronavirus Retinopathy
L.C. Hooper1, M.S. Chin1, Y.Wang2, B.Detrick3, J.J. Hooks1
Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD; 2Department of Microbiology and Immunology, Georgetown University Medical Center, Rockville, MD; 3Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Microarray Gene Expression in Pterygia
M. John-Aryankalayil1, C.J.Jaworski1, T.W. Reid2, N. Dushku3, K.E.Pearson4, D.A. Stephan4, D.A. Carper1 SMT, LMOD, NEI1, Ophth. & Visual Sci., Texas Tech Univ HSC, Lubbock, TX2, Kaiser Permanente Medical Center, Sacramento, CA3; Children's National Medical Center, Washington, D.C.4
Major pathogenic epitope(s) of human retinal soluble antigen (h-SAg) in a humanized model of experimental autoimmune uveitis in HLA class-II transgenic mice.
Z. Karabekian, G. Pennesi, M. Mattapallil, and R. Caspi.
Mitochondria permeability changes due to regulation of Bid expression in human retinal pigment epithelium (HRPE)
A. Katikineni1, C. Zhang, K.G. Csaky, 1Summer student, NEI, NIH, Bethesda, Maryland
Regulatory Elements Activating the Lens-specific MIP/ Aquaporin 0 Gene Promoter in Differentiated Lens Epithelia
Sanjiv Kumar, Nady Golestaneh and Ana B. Chepelinsky
Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.
Variants of CTACK (CCL27) are Expressed in Mouse Eye
1Dolena Ledee, 2Igal Gery and 1Peggy Zelenka
1Laboratory of Molecular and Developmental Biology, and 2Laboratory of Immunology, NEI, NIH.
Bietti Crystalline Corneoretinal Dystrophy is caused by CYP4V2: A Novel Member of the Cytochrome P450 Family
A. Li1, X. Jiao1, F. Munier2, D. Schordoret2, W.Yao1 F. Iwata3, M. Hayakawa3, A. Kanai3, M.S. Chen4, R. Lewis5, J. Heckenlivey6, M.Kaiser-Kupfer1, Y. Sergeev1, and J.F. Hejtmancik1
Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD1; Oculgenetic Unit, Jules Gonin Eye Hospital and Division of Medical Genetics, Lausanne, Switzerland2; Juntendo University, School of Medicine, Juntendo, Japan3; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan4; Department of Ophthalmology and Human and Molecular Genetics, Baylor College of Medicine, Houston, TX5; Jules Stein Eye Institute/UCLA, Los Angeles, CA6
Expression of Glucocorticoid Induced TNF Receptor Family Related Protein (GITR) on peripheral T cells from normal human donors and patients with non-infectious uveitis
Zhuqing Li1, Sankaranarayana P Mahesh1, Ben J Kim1, 2, Ronald R Buggage1, Robert B Nussenblatt1
1Laboratory of Immunology, NEI, NIH, 2Howard Hughes Medical Institute
Alpha tropomyosin as a self-antigen in patients with Behcet's syndrome
S.P Mahesh, Zhuqing Li, R.B. Nussenblatt
Laboratory of Immunology, National Eye Institute, Bethesda, MD
Identification of Candidate Genes for Autoimmune Uveoretinitis Using QTL and cDNA Microarray Analysis in Rat Model
Mattapallil, M1; Pennesi, G1; Cheadle, C2; Teichberg, D2; Remmers, E3; Becker, KG2 and Caspi, RR1
1Immunoregulation section, Laboratory of immunology,NEI; 2Laboratory of cellular and molecular Biology and DNA array unit, Intramural research program,NIA; 3Inflammatory Joint Diseases section, Arthritis and Rheumatism Branch, NIAMS; National Institutes of Health, Bethesda, MD 20892.
Differential expression of PDGF and their receptors in human RPE and choroidal cells: Potential role in choroidal neovascularization (CNV) and proliferative vitreoretinopathy (PVR)
Chandrasekharam N. Nagineni 1, Veena Kutty 1, Barbara Detrick 2, John J. Hooks 1
1Laboratory of Immunology, NEI, NIH, Bethesda, MD; 2Department of Pathology, JHMI, Baltimore, MD.
Interactions of pigment epithelium-derived factor with a novel polypeptide: A putative receptor
Luigi Notari, Christina Meyer, and S. Patricia Becerra
Laboratory of Retinal Cell and Molecular Biology
Subcutaneously Administered Daclizumab Therapy for Uveitis
Robert B. Nussenblatt, MD1, Narsing A. Rao, MD2, C. Stephen Foster, MD3, H. Nida Sen, MD1, Roxana Ursea, MD1, Zhuqing Li, MD, PhD1, Susan Mellow,RN1, Darby J Thompson, MS4, Jan S. Peterson, MS4, Randy R. Robinson, PhD5, Richard S. Shames5, MD, Ronald R. Buggage, MD1
1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 2Doheny Eye Institute, Los Angeles, CA 3Massachusetts Eye and Ear Infirmary, Boston, MA, 4The EMMES Corporation, Rockville, MD, 5Protein Design Labs, Inc, Fremont CA
A Central Role for Iris-Expressed Growth Factor/PDGFD in Proliferation of Lens Epithelial Cells and Control of Lens Growth
S.Ray, R.Fariss, K.Wyatt, C. Gao, P.Zelenka, G.Wistow.
NEI/NIH, Bethesda, MD.
Fenretinide Induces Apoptosis in Human Retinal Pigment Epithelial (RPE) Cells: The Role of Retinoid Receptors
W. Samuel1, R.K. Kutty1, R.A.S. Chandraratna2, B. Wiggert1
1Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2740; 2Departments of Chemistry and Biology, Retinoid Research, Allergan Pharmaceuticals, Irvine, California 92713-9534;
Dietary Omega-3 Long-chain Polyunsaturated Fatty Acids and Risk for Age-related Macular Degeneration
J.P. SanGiovanni, E.Y. Chew, R.D. Speduto, N.Kurinij, F.L. Ferris, and AREDS Research Group.
Intravitreal Methotrexate Resistance in a Patient with Primary Intraocular Lymphoma
H. Nida Sen MD, Chi-Chao Chan MD, Gordon Byrnes MD, Robert N. Fariss, PhD, Rafael Caruso, MD, Robert B. Nussenblatt MD, Ronald R. Buggage MD
Confocal analysis of retina ganglion cells retrogradely labeled with DiI in fixed mouse eyes.
Vladimir V Senatorov*, Robert Fariss**, Stanislav I Tomarev*
*Laboratory of Molecular and Biological Development and **Laboratory of Mechanisms of Ocular Diseases, National Eye Institute
Lack of Ocular Response to Lipopolysaccharide in CCR-1 Deficient Mice
D.F. Shen,1 N. Tuaillon,1 J. A. Peterson,1 B. Lu,2 C. C. Chan1
1. Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD. 2. Children's Hospital, Harvard Medical School, Boston, MA.
Complex regulation of biphasic CD4OL expression in PBMC
Jijia Shen, Claudette L. Fuller, Jack A. Ragheb.
LI, NEI/ NIH, 9000 Rockville Pike, Bethesda, MD 20892-1857
Dry eye signs and symptoms in women with premature ovarian failure
Janine A. Smith, MD1, Susan Vitale, PhD, MHS1, George F. Reed, PhD,1, Shirley A. Grieshaber, RN, CRNO 2, Linda A. Goodman, COT 2, Vien H. Vanderhoof, RN, CRNP 3Karim A. Calis, PharmD, MPH3, Lawrence M. Nelson, MBA, MD 3
1 Division of Epidemiology and Clinical Research, National Eye Institute, 2 Clinical Center, 3 Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
Specifics of the Nonllethal Injury Response In Retinal Pigment Epithelial Cells (RPE) on Cellular and Molecular Levels
N. Strunnikova (1), J. Baffi (1), C. Zang (1), D. Teichberg (2), K. Becker (2). and K. Csaky (1)
National Eye Institute, NIH, Bethesda, MD (1),National Institute of Aging, Baltimore MD (2),
Cholera toxin prevents Th1-mediated autoimmune disease by enhancing Th2 polarization
Shao Bo Su, Phyllis B. Silver, Peng Wang, Chi-Chao Chan and Rachel R. Caspi
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
Expression and Localization of Retinoschisin (RS-1) in the Developing Mouse Retina
Yuichiro Takada, Robert Fariss, Atsuhiro Tanikawa, Ronald A. Bush, Paul A. Sieving
National Eye Institute, National Institutes of Health, Bethesda, MD.
Expression of Retinal Antigens in Human Thymi: Variability among Antigens and Individual Thymi
Takase, H. (1), Yu, C. R. (1), Mahdi, R. M. (1), DiRusso, G. (2), Midgley, F. (2), Douek, D. (3), Pugliese, A. (4), Egwuagu, C. E. (1), Gery, I. (1)
(1) Laboratory of Immunology, NEI, (2) Children's National Medical Center, Washington, DC, (3) Vaccine Research Center, NIAID, (4) Diabetic Research Institute, University of Miami School of Medicine, Miami, FL.
The Cone ERG During Light Adaptation In Mice Lacking Functional Rods
1Atsuhiro Tanikawa, 1Ronald A. Bush, 1Yuichiro Takada, 2Alan J. Mears, 2Anand Swaroop, 1Paul A. Sieving
1National Eye Institute, NIH, Bethesda, MD, 2 Department of Ophthalmology and Visual Science, Kellogg Eye Center, University of Michigan, Ann Arbor, MI
Eyelid Myxoma in Carney Complex: Histo-Pathology & Genetics
E.T. Tsilou1, C.C. Chan2, B.I. Rubin1, D. Shen2, F. Sandrini3, C.A. Stratakis3, M. Kaiser-Kupfer1.
Ophthalmic Genetics and Visual Function Branch1, Lab of Immunology2, NEI; Unit on Genetics & Endocrinology, Developmental Endocrinology Branch, NICHD3, National Institutes of Health.
Endotoxin-Induced Uveitis in Cyclooxygenase 2 Deficient Mice
Jingsheng Tuo, Nadine Tuaillon, DeFen Shen, and Chi-Chao Chan
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
The Role of Ultrasound Biomicroscopy in Assessment of Patients with Anterior Segment Ocular Inflammatory Disease
R.Ursea, R.B. Nussenblatt, J.A. Smith, L.Ayres, R.C. Caruso, H.N. Sen, R.R. Buggage
National Eye Institute, National Institutes of Health, Bethesda, MD.
Macrophage driven transgenic expression of IL-10 ameliorates induction of Experimental Autoimmune Uveitis (EAU)
Angelia M. Viley1, Rajeev K. Agarwal1, Phyllis B. Silver1, Rafael Grajewski1, Mitchell Kronenberg2, Peter J. Murray3, Robert L. Rutschman3, Chi-Chao Chan1, and Rachel R. Caspi1
1Lab. of Immunology, NEI, NIH, Bethesda, MD 20892; 2Molecular Biology Institute, Dept of Microbiology & Immunology, UCLA, Los Angeles, California 90095; and 3Dept of Infectious Diseases, St. Jude Children's Hospital, Memphis, TN 38105.
Localized T-lymphoid Proliferation in Eyes of Transgenic Mice Expressing IL-7 Selectively in their Lens
Barbara Vistica1, Jun Chen1, Hiroshi Takase1, Don-Il Ham1, Eric Wawrousek2, Scott Durum3, Chi-Chao Chan1, and Igal Gery1.
1Laboratory of Immunology, 2Laboratory of Molecular and Developmental Biology, National Eye Institute, 3Laboratory of Molecular Immunoregulation, National Cancer Institute, NIH.
Comparison of a generic (NEI-VFQ) and a disease-specific (OSDI) questionnaire in patients with Sjogren's syndrome.
Susan Vitale, Linda Goodman, George F. Reed, and Janine Smith
Division of Epidemiology and Clinical Research, National Eye Institute, NIH, Bethesda, MD.
Knock-out mice for gS-crystallin
G. Wistow1, L. Dong1, K. Wyatt1, J. Kuzak2.
1MSF, NEI, and 2Rush University Medical School, Chicago IL
Lengsin: A Novel Marker for Terminal Differentiation in the Lens
G.Wistow1, K.Wyatt1, Chun Gao1, S.Bernstein2, E.Orlova3, L.Wang3, C.Slingsby3
1National Eye Institute, Bethesda, MD; 2Dept. Ophthalmology, U. Maryland Sch. Med., Baltimore, MD; 3Department of Crystallography, Birkbeck College, London, United Kingdom.
Solution Structure of gS-crystallin from Residual Dipolar Couplings
Zhengrong Wu, Keith Wyatt, Graeme Wistow and Ad Bax.
LCP/NIDDK and MSF, NEI, NIH, Bethesda, MD 20892
gN: A novel member of the g-Crystallin family.
M.K.Wyatt1, L.David2, S. Bernstein3 and G. Wistow1.
1MSF, NEI, 2Oregon Health Sciences University, Portland, OR, 3Dept. Ophthalmology, U. Maryland School of Med., Baltimore, MD.
Interaction of RPE65 with caveolin-1
SS Yu, RN Fariss, E Poliakov, S Gentleman and TM Redmond
Laboratories of Retinal Cell & Molecular Biology and Mechanisms of Ocular Disease, National Eye Institute, NIH, Bethesda, MD 20892
Adenovirus-associated virus (AAV) mediated delivery of lens epithelium derived growth factor (LEDGF) protects rat photoreceptors from light-damage
1Yong Zeng, Dorit Raz-Prag, 2Rong Wen, Maria Santos-Muffley, Paul A. Sieving and Ronald A. Bush
1National Eye Institute, National Institutes of Health, Bethesda, MD. 2Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA
Regulation of C-Flip sensitizes Human Retinal Pigment Epithelium (HRPE) To Tumor Necrosis Factor ¡V a (TNF-a) Induced programmed cell death.
C. Zhang1, N. J. Caplen2, N. Strunnikova1, J. Baffi1 A. Katikineni1 C.C. Chan1 , S.W. Cousins3, K.G. Csaky1
1NEI, 2NHRI, NIH, Bethesda, Maryland, 3BPEI, University of Miami, Miami, Florida
Effects of TGFbeta on Human Trabecular Meshwork Cells Open a New Window for Understanding Glaucoma Pathophysiology and Potential Glaucoma Therapy
Xiujun Zhao, M.D.; Paul Russell, Ph.D.
LMOD, NEI, NIH
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