Douglas Kim, Ph.D.
Postdoctoral Fellow
Douglas Kim received an A.B from Princeton University, Department of Molecular Biology (1992-1996) and his Ph.D., University of Washington, Molecular and Cellular Biology Program (1996-2002). He served as a postdoctoral fellow, Harvard Medical School, Department of Genetics, (2002-2008).
Douglas is interested in studying the molecular basis of retinal development and degeneration. He is currently investigating the process of rod and cone photoreceptor cell synaptogenesis with postsynaptic targets using a combination of mouse mutants, in vivo mouse retinal DNA transfection, and time-lapse imaging. He is also developing functional screening tools to study photoreceptor cell development using RNA-mediated interference in the mouse retina in vivo.
Publications:
Szczypka, M.S., Rainey, M.A., Kim, D.S., Alaynick, W.A., Marck, B.T., Matsumoto, A.M., Palmiter, R.D. (1999) Feeding behavior in dopamine-deficient mice. Proc. Natl. Acad. Sci. USA 96:12138-12143.
Kim, D.S., Szczypka, M.S., Palmiter, R.D. (2000) Dopamine-deficient mice are hypersensitive to dopamine receptor agonists. J. Neurosci. 20:4405-4413.
Kim, D.S., Froelick, G.J., and Palmiter, R.D. (2002) Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. J. Neurosci. 22:9841-9849.
Kim, D.S., and Palmiter, R.D. (2003) Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice. Proc. Natl. Acad. Sci. USA 100:1346-1351.
Denenberg, V.H., Kim, D.S., and Palmiter, R.D. (2004) The role of dopamine in learning, memory, and performance of a water escape task. Behav. Brain Res. 148:73-78.
Kim, D.S., Palmiter, R.D., Cummins, A., and Gerfen, C.R. (2006) Reversal of supersensitive striatal dopamine D1 receptor signaling and Extracellular Signal-Regulated Kinase (ERK) activity in dopamine-deficient mice. Neuroscience 137:1381-1388.
Kim, D.S., and Palmiter, R.D. (2008) Interaction of dopamine and adenosine receptor function in behavior: Studies with dopamine-deficient mice. Front. Biosci. 13:2311-2318.
Kim, D.S., Ross, S.E., Trimarchi, J.M., Aach, J., Greenberg, M.E. and Cepko, C.L. (2008) Identification of molecular markers of bipolar cells in the murine retina. J. Comp. Neurol. 507:1795-1810.
Lagali, P.S., Balya, D., Awatramani , G.B., Munch, T.A., Kim, D.S., Busskamp, V., Cepko, C.L., and Roska, B. (2008) Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat. Neurosci. 11:667-675.
Kim, D.S., Matsuda, T., and Cepko, C.L. (2008) A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression. J. Neurosci. 28:7748-7764.
