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Home » Resources » Clinical Studies » The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated with Juvenile Rheumatoid Arthritis

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The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated with Juvenile Rheumatoid Arthritis

Purpose | Background | Description | Patient Eligibility | Recruitment Status | Current Status | Results | Publications | Resource Centers | NEI Representative

Purpose

To investigate the safety and effectiveness of the drug EnbrelŪ (TNFR:Fc) to treat uveitis (eye inflammation) in patients with juvenile rheumatoid arthritis.

Background

In other studies, TNFR:Fc significantly reduced joint pain and swelling in adult patients with rheumatoid arthritis, and the Food and Drug Administration has approved the drug for that use. Because medicines for arthritis often help patients with eye inflammation, this study will examine whether TNFR:Fc can help patients with uveitis.

Description

Patients with uveitis who are not responding well to standard treatment, such as steroids, and patients who have side effects from other medicines used to treat their uveitis or have refused treatment because of possible side effects may be eligible for this study. Candidates will be screened with a medical history, physical examination, and eye examination. The eye exam includes a check of vision and eye pressure, examination of the back of the eye (retina), and front of the eye, including measurements of protein and inflammation. Candidates will also undergo fluorescein angiography-a procedure in which photographs are taken of the retina to see if there is any leakage in the eye's blood vessels. A blood test and joint evaluation will also be done.

Study participants will be given an injection of TNFR:Fc twice a week for up to 12 months and may continue other medicines they may be taking, such as prednisone or methotrexate. They will have follow-up examinations at week two and months one, two, three and four. Those who wish to continue treatment after the fourth month can receive the drug for another eight months and will have follow-up exams at months six, nine and 12, and one month after treatment ends. Each follow-up visit will include a repeat of the screening exams and an evaluation of side effects or discomfort from the medicine.

Patient Eligibility

Patient Recruitment Status

Completed.

Current Status of Study

Ongoing.

Results

None.

Publications

None.

NEI Representative

Prinicipal Investigator
Janine A. Smith, M.D.
National Eye Institute
National Institutes of Health
Building 10, Room 10N202
10 Center Drive
Bethesda, MD 20892

Last Updated: 1/4/02



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