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Home » Strategic Planning » Strategies to Investigate the Pathophysiology of Ganglion Cell and Optic Nerve Degeneration--Agenda

Strategies to Investigate the Pathophysiology of Ganglion Cell and Optic Nerve Degeneration

Airlie Conference Center, Airlie, Virginia
November 12-13, 2002

Agenda

Conference Center
Tuesday, November 12, 2002
* Check-in prior to 12 noon
12 noon - 1:00 p.m. Lunch
1:00 p.m. - 2:15 p.m. Current Hypotheses of Glaucoma Pathophysiology
  1:00 p.m. - 1:25 p.m. Donald Zack, M.D., Ph.D., Johns Hopkins
What is glaucoma?
What is the role of intraocular pressure in the etiology of glaucoma?
  1:25 p.m. - 1:40 p.m. Alan M. Laties, M.D., University of Pennsylvania
What is the vascular component of glaucoma?
  1:40 p.m. - 2:00 p.m. M. Rosario Hernandez, D.D.S., Washington University
What damages the optic nerve head in glaucoma?
  2:00 p.m. - 2:15 p.m. Discussion
2:15 p.m. - 3:10 p.m. What Can Animal Models Contribute to the Study of Glaucoma?
  2:15 p.m. - 2:35 p.m. John C. Morrison, M.D., Oregon
Primate and rat models of ocular hypertension
  2:35 p.m. - 2:55 p.m. Simon John, Ph.D., Jackson Labs
Mouse models of inherited ON/GC degeneration
  2:55 p.m. - 3:10 p.m. Discussion
3:10 p.m. - 3:30 p.m. Break
3:30 p.m. - 5:00 p.m. How is the Biology of the Inner Retina Affected in Glaucoma?
  3:30 p.m. - 3:55 p.m. Ben A. Barres, M.D., Ph.D., Stanford University
Retinal ganglion cell interactions and survival
  3:55 p.m. - 4:20 p.m. Carla J. Shatz, Ph.D., Harvard University
Function and retinal development
  4:20 p.m. - 4:45 p.m. David Copenhagen, Ph.D., UCSF
Glutamate and synaptic transmission
  4:45 p.m. - 5:00 p.m. Discussion
5:00 p.m. - 6:00 p.m. Are Mechanisms of Chronic Neurodegeneration Relevant to Glaucoma Etiology?
  5:00 p.m. - 5:25 p.m. Jeff Rothstein, M.D., Ph.D., Johns Hopkins
Amyotrophic lateral sclerosis
  5:25 p.m. - 5:50 p.m. Valina L. Dawson, Ph.D., Johns Hopkins
Parkinson's Disease and Stroke
  5:50 p.m. - 6:00 p.m. Discussion
6:00 p.m. - 7:15 p.m. Break/Dinner
7:15 p.m. - 9:00 p.m. Degeneration/Regeneration
  7:15 p.m. - 7:40 p.m. Eugene M. Johnson, Ph.D., Washington University
Growth factor deprivation and neuronal cell death.
  7:40 p.m. - 8:05 p.m. Ben A. Barres, M.D., Ph.D., Stanford Medical School
What are the factors that promote RGC survival and axon regeneration?
  8:05 p.m. - 8:30 p.m. Bruce R. Ransom, M.D., Ph.D., University of Washington
The optic nerve as a model of CNS ischemic damage.
  8:30 p.m. - 9:00 p.m. Discussion/Plans for Next Day
 
Wednesday, November 13, 2002
7:30 a.m. - 8:30 a.m. Breakfast
8:30 a.m. - 8:55 a.m. What is known about the microenvironment in the optic nerve-head?
  8:30 a.m. - 8:55 a.m. Arthur H. Neufeld, Ph.D., Washington University
Role of NO in RGC Degeneration
9:00 a.m. - 9:40 a.m. Presentation on topics to be decided based on day one discussions
9:40 a.m. - Noon Discussion Topics
  9:40 a.m. - 10:10 a.m. Can we identify key points that trigger the mechanisms of disease?
Leaders: Eugene M. Johnson, Ph.D./Donald Zack, M.D., Ph.D..
  10:10 a.m. - 10:30 a.m. Break
  10:30 a.m. - 11:00 a.m. Can we devise protective strategies for RGC?
Leaders: Valina L. Dawson, Ph.D./Arthur H. Neufeld, Ph.D..
  11:00 a.m. - 11:30 a.m. What are the key systems and models that can be explored in RGC neuroprotection?
Leaders: Bruce R. Ransom, M.D., Ph.D./M. Rosario Hernandez, D.D.S..
  11:30 a.m. - Noon Where do we go next?
Leader: Ruben Adler, M.D..
Noon - 2:00 p.m. Working lunch and Recommendations for 5 Priority Areas
  2:30 p.m. Rides to Dulles Airport to arrive by 3:30 pm for 5 pm flights.
  2:30 p.m. Rides to Reagan-National Airport to arrive by 3:45 pm for 5 pm flights.


Department of Health and Human Services NIH, the National Institutes of Health USA.gov