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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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Graph showing that odd ratio for advanced vision loss for African Americans is significantly higher than for non-hispanic whites.

Black patients found six times more likely to have advanced vision loss after glaucoma diagnosis than white patients

July 25, 2022

Black patients have a dramatically higher risk of advanced vision loss after a new diagnosis of primary open angle glaucoma (POAG) when compared to white patients, according to a new study from New York Eye and Ear Infirmary of Mount Sinai (NYEE).
Kathryn Bollinger Sylvia Smith

Protein protects brain cells most impacted by glaucoma

March 3, 2022

Protein sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of retinal ganglion cells (RGCs) in culture.
A diagram of the eye with a green arrow showing how fluid normally passes through the space between the iris and the cornea and drains out of the eye back into the bloodstream.

A new treatment for glaucoma?

October 18, 2021

A Northwestern Medicine study in mice has identified new treatment targets for glaucoma, including preventing a severe pediatric form of glaucoma, as well as uncovering a possible new class of therapy for the most common form of glaucoma in adults.
AGI identity mark

Learning how transplanted neurons fit in

October 7, 2021

As scientists move closer to testing regenerative therapies for eye disease, techniques are needed to monitor transplanted cells as they integrate with host tissues.
Female shown from overhead standing with her eye open receiving OCT scan.

NEI-funded technology promises to broaden access to retinal scanning

July 22, 2021

A National Eye Institute-funded project at Duke University has yielded a fully automated optical coherence tomography (OCT) device that does not require a trained operator and promises to broaden access to retinal imaging technology.
Eye is shown connected to visual processing regions of the brain via the optic nerve. Enlargement of retina shows photorecetors, biopolar cells and retinal ganglion cells.

Scientists discover gene therapy provides neuroprotection to prevent glaucoma vision loss

July 22, 2021

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma.
A mug of coffee

High caffeine consumption may be associated with increased risk of blinding eye disease

June 7, 2021

Consuming large amounts of daily caffeine may increase the risk of glaucoma more than three-fold for those with a genetic predisposition to higher eye pressure according to an international, multi-center study.
Slice of OCT image hovers over 3D segmentation of retinal cells

AI Spots Individual Neurons in the Eye Better than Human Experts

May 4, 2021

A new combination of optical coherence tomography (OCT), adaptive optics and deep neural networks should enable better diagnosis and monitoring for neuron-damaging eye and brain diseases like glaucoma.

Treatment not always needed to prevent vision loss in patients with elevated eye pressure

April 15, 2021

More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma.
Doctor examines patient's eye using slit lamp

Citicoline protects against glaucoma without reducing fluid pressure in eye

April 14, 2021

A new study showed that ingesting the compound citicoline restored optic nerve (neural) signals between the brain and eye to near-normal levels in the study rats.

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