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28 items
Samarendra Mohanty and Subrata Batabyal

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice

October 22, 2020

A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovati
Zebrafish

Could a tiny fish hold the key to curing blindness?

September 25, 2020

NEI-funded scientists are hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease.
City scene at night. Credit: Luca Bravo on Unsplash

How is night vision maintained during retinal disease?

September 24, 2020

New research from the University of Utah provides insight on how people with retinal degenerative disease can maintain their night vision for a relatively long period of time.
What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules.     The ability to obtain high-resolution imaging of tissue as large as whole mouse re

LSU Health show nonharmful stress protects against disease in offspring

September 11, 2020

Researchers funded by the National Eye Institute show in a mammalian model the reprogramming of heritability to promote disease resilience in the next generation.
High-resolution three dimensional view of the human retina acquired with adaptive optics line-scan OCT showing the different layers and individual cone photoreceptors as white circular spots. Credit: Ramkumar Sabesan, Ph.D.

Seeing the eye like never before

September 9, 2020

Scientists at the University of Washington School of Medicine detect minute changes in response to light in photoreceptors in a living eye.
Eye scans showing retinal vein occlusion with and without Casp-9 inhibitor

New Eye Drops May Prevent a Common Cause of Blindness

June 29, 2020

Researchers at Columbia University Irving Medical Center have developed eye drops that could prevent vision loss after retinal vein occlusion, a major cause of blindness for millions of adults worldwide.
Grantee News

LSU Health discovers critical role of two proteins in vision and preventing blinding eye diseases

December 10, 2019

LSU researchers have discovered unique patterns of genetic activity that may lead to the development of blinding retinal diseases.
Microglia in retinal sections of a patient with retinitis pigmentosa

Immune System Can Slow Degenerative Eye Disease, NIH-led Mouse Study Shows

June 17, 2019

A new study shows that the complement system, part of the innate immune system, plays a protective role to slow retinal degeneration in a mouse model of retinitis pigmentosa, an inherited eye disease.
Split panel showing microglia and blood vessels in healthy retina or in retina without TGFβ signaling.

Faulty molecular master switch may contribute to AMD

January 22, 2019

A signaling pathway controlled by transforming growth factor β (TGF-β) could be involved in the progression of age-related macular degeneration (AMD).
Multiphoton images show the outer segments of cone and rod photoreceptor cells in 215-day retinal organoids. Immunostaining shows a marker for cones (green) and rods (red). The “A” view shows optical sections; “B” is a reconstructed three-dimensional view.

NEI Awards Prize for Progress Toward Developing Lab-Made Retinas

December 4, 2018

The National Eye Institute (NEI) awarded $25,000 to a team led by Wei Liu, Ph.D., Albert Einstein College of Medicine, for demonstrating progress toward the development of a living model of the human retina...