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61 items
diagram of the eye

Unique Schwann Cells: The Eyes Have It

November 20, 2020

A new study from University of Connecticut details a method of characterizing every cell in the cornea using an approach known as single-cell RNA sequence analysis to answer questions about the cornea’s healing process.
Samarendra Mohanty and Subrata Batabyal

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice

October 22, 2020

A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovati

UCI-led study reveals significant restoration of retinal and visual function following gene therapy

October 19, 2020

New generation CRISPR technology lays foundation for therapeutics to treat a wide range of inherited ocular diseases
Scientist viewed through a laboratory shelf filled with bottles

AGI-supported researchers discover gene pathways that regenerate neurons between the eye and the brain

October 5, 2020

A team of researchers has identified networks of genes that allow neurons to regenerate in animals like zebrafish.
What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. The image is from a research project investigating the promise of gene therapy for glaucoma. It was created at an NIGMS-funded advanced microscopy facility that develops technology for imaging across many scales, from whole organisms to cells to individual molecules.     The ability to obtain high-resolution imaging of tissue as large as whole mouse re

LSU Health show nonharmful stress protects against disease in offspring

September 11, 2020

Researchers funded by the National Eye Institute show in a mammalian model the reprogramming of heritability to promote disease resilience in the next generation.
David Gamm in the laboratory

UW researchers devise approach to treat rare, incurable form of blindness

July 30, 2020

Scientists at the University of Wisconsin‒Madison have published a proof-of-concept method to correct an inherited form of macular degeneration that causes blindness, and that is currently untreatable.
Computerized image of an eyeball, optic nerve and brain.

Study points to potential new approach to treating neurodegenerative diseases like glaucoma and Alzheimer’s disease

July 20, 2020

Researchers have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.
Multicolor image of retina in cross-section

Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents

July 7, 2020

In experiments in rats and mice, two Johns Hopkins scientists report the successful use of nanoparticles to deliver gene therapy for blinding eye disease.
Cross-section of mouse eye showing lens, non-pigmented ciliary epithelium (green with sections of red at 12 o’clock and 6 o’clock), and zonular fibers (blue). Green corresponds to fibrillin-depleted NPCE. The space between the arrows indicates where the zonular fibers have snapped.

New research on Marfan syndrome focuses on eyes

June 12, 2020

New NEI-supported research provides insight into the eye conditions associated with Marfan syndrome, where weakened zonule fibers cause vision problems.
Man getting his eyes examined by a doctor using a slit lamp

Retinitis pigmentosa research probes role of the enzyme DHDDS in this genetic disease

June 10, 2020

Researchers who made a knock-in mouse-model of the genetic disorder retinitis pigmentosa 59, or RP59, found no retinal degeneration or thinning, calling into question the commonly accepted mechanism for RP59.