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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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Multicolor image of retina in cross-section

Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents

In experiments in rats and mice, two Johns Hopkins scientists report the successful use of nanoparticles to deliver gene therapy for blinding eye disease.
Field of green cells with red circle and red oval overlaid.

New gene therapy delivery system aims for precision

In a novel approach to gene therapy, scientists funded by the National Eye Institute (NEI) report using gold nanoparticles and light to target specific cells in mouse retina.
Eye chart for testing vision

Therapy could improve, prolong sight in those suffering vision loss

Millions of Americans are progressively losing their sight as cells in their eyes deteriorate, but a new therapy developed by researchers at the University of California, Berkeley, could help prolong useful vision and delay total blindness.
Image of retina

Scientists successfully test new way to deliver gene therapy​

Researchers at Case Western Reserve University have used a unique method to safely deliver gene therapy to fight a rare, but irreversible, genetic eye disorder known as Stargardt disease.
Rhesus macaque monkey

Discovery in monkeys could lead to treatment for blindness causing syndrome

Oregon National Primate Research Center at OHSU reports first-ever nonhuman primate model for Bardet-Biedl Syndrome
Grantee News

Nano-sized solution for efficient and versatile CRISPR gene editing

CRISPR gene-editing technology holds tremendous promise for treating or curing a wide range of devastating disorders, including vision loss.
Grantee News

Success of gene therapy for a form of inherited blindness depends on timing

Using a canine model of the vision disorder Leber congenital amaurosis, Penn researchers found that photoreceptor cells continue to deteriorate after treatment if it is given too late.
Grantee News

With Single Gene Insertion, Blind Mice Regain Sight

Researchers at the University of California, Berkeley, find that restoring opsins with gene therapy can make 'blind' cells light-sensitive; potential human treatment within three years.
Photo shows T. Michael Redmond, Ph.D.

NIH vision researcher T. Michael Redmond recognized with Champalimaud Vision Award

Vision researcher, T. Michael Redmond, Ph.D., chief of the National Eye Institute (NEI) Laboratory of Retinal Cell and Molecular Biology, is a recipient of the 2018 António Champalimaud Vision Award for foundational science discoveries about the molecular
Illustration of icosahedral virus capsid, containing circular AAV vector. Arrows point from green and blue colored regions of the vector to shRNA and rhodopsin protein, respectively.

Researchers find potential new gene therapy for blinding disease

Scientists funded by the National Eye Institute (NEI) report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP).