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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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Grantee News

Handheld Device Takes High-Resolution Images of Children's Retinas

Engineers and physicians at Duke University have developed a handheld device capable of capturing images of a retina with cellular resolution.
James W. Gollady, Jr., Right Eminent Department Commander (right), presents Hotaling with a check from the Knights Templar Eye Foundation. “I think this award is extremely important to pave a pathway for me in medical research,” said Hotaling. (Joe Balintfy, NEI)

NEI Scientist Receives Research Grant from Knights Templar Eye Foundation

NEI research fellow Nathan Hotaling, PhD, has been awarded a $65,000 grant from the Knights Templar Eye Foundation to develop a stem cell-based system to study Best disease, a genetic disorder that can cause progressive vision loss.
Grantee News

CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells

Columbia University Medical Center (CUMC) and University of Iowa scientists have used a new gene-editing technology called CRISPR to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition.
Grantee News

Gene Editing Technique Improves Vision in Rats with Inherited Blindness

A new technique that has the potential to treat inherited diseases by removing genetic defects has been shown for the first time to hinder retinitis pigmentosa, a degenerative eye disease with no known cure that can lead to blindness.
Grantee News

USC Eye Institute researchers discover a way to improve image sharpness for blind people with retinal implants

Retinal implants that deliver longer pulses of electrical current may noticeably improve image sharpness for individuals who have lost their sight due to retinitis pigmentosa, according to a new study.
Grantee News

Researchers Grow Retinal Nerve Cells in the Lab

Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain.
Image of gene therapy preserved vision in a study involving dogs.

Gene Therapy Staves Off Blindness from Retinitis Pigmentosa in Canine Model

Gene therapy preserved vision in a study involving dogs with naturally occurring, late-stage retinitis pigmentosa, according to research funded by the National Eye Institute (NEI), part of the National Institutes of Health.
Dr. John Guy and colleagues added a homing signal to a virus in order to deliver the ND4 gene into mitochondria. A marker for the gene is shown in red and the ND4 protein is shown in green, inside retinal ganglion cells in the mouse eye. The nuclei of retinal ganglion cells are shown in blue. Credit: Dr. Hong Yu, Bascom Palmer.

Scientists Test New Gene Therapy for Vision Loss From a Mitochondrial Disease

Researchers funded by the National Institutes of Health have developed a novel mouse model for the vision disorder Leber hereditary optic neuropathy (LHON), and found that they can use gene therapy to improve visual function in the mice.
Mice with AQP0 mutations (top) had disorderly fiber cells compared to mice with healthy AQP0.

Defective Lens Protein Implicated in Cataract Shown Culprit in Presbyopia

Loss or defects of a protein previously shown to play a key a role in cataract, the clouding of the lens that commonly strikes people in their seventies, has now been shown to contribute to presbyopia.
Artist's rendering of neural activity in the retina. Light that enters the eye activates rod and cone photoreceptors, which in turn activate retinal ganglion cells. Signals travel to the brain via retinal ganglion cell axons. Photo credit: National Eye Institute.

NIH Launches Research to Gaze Deeply Into Your Eyes

Five bold projects will develop new technology to noninvasively image cells of the eye in unprecedented detail.The National Eye Institute (NEI) announced the awards as part of its Audacious Goals Initiative.

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