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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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37 items
Comparison of two retinal images.

Gene therapy for rare eye disease safe but lacks efficacy in early trial

mayo 31, 2022

A 28-patient phase 1 gene therapy clinical trial for the degenerative retinal disease Leber hereditary optic neuropathy (LHON) found no significant safety concerns; however, treatment failed to improve or slow vision loss, with even the highest dose.
Neurons (green) and their supporting astrocytes (red), created in a petri dish from stem cells.

Cell-replacement Therapies for Visual System Disorders

julio 30, 2021

Two translational studies at the Vanderbilt Eye Institute are targeting photoreceptors and retinal ganglion cells (RGCs) to restore vision through regeneration of the retina. The research is funded by the NEI Audacious Goals Initiative.
Image of brain cells with "sparks" of red and yellow

Brain tumors caused by normal neuron activity in mice predisposed to such tumors

mayo 26, 2021

A study by researchers at Washington University School of Medicine in St. Louis and Stanford University School of Medicine shows that the normal day-to-day activity of neurons can drive the formation and growth of brain tumors.

Treatment not always needed to prevent vision loss in patients with elevated eye pressure

abril 15, 2021

More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma.
Image shows eye globe, optic nerve, lens, cornea, pupil, meshwork, angle, and where fluid forms and exits the front of the eye.

Cataract surgery in infancy increases glaucoma risk

diciembre 17, 2020

Children who undergo cataract surgery as infants have a 22% risk of glaucoma 10 years later, whether or not they receive an intraocular lens implant. The findings come from the National Eye Institute (NEI)-funded Infant Aphakic Treatment Study.
NEI Audacious Goals Initiative for regenerative medicine in vision identity mark

Eye institute’s audacious quest: What once was lost might now be regrown

octubre 13, 2020

The National Eye Institute (NEI) Audacious Goals Initiative (AGI) is exploring the possibility that the natural world holds the keys to restorative therapies that might unlock regenerative powers in humans.
Zebrafish

Could a tiny fish hold the key to curing blindness?

septiembre 25, 2020

NEI-funded scientists are hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease.
Computerized image of an eyeball, optic nerve and brain.

Study points to potential new approach to treating neurodegenerative diseases like glaucoma and Alzheimer’s disease

julio 20, 2020

Researchers have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.
diagram of the eye

Temple Scientists Regenerate Neurons in Mice with Spinal Cord Injury and Optic Nerve Damage

abril 30, 2020

New research by scientists at the Lewis Katz School of Medicine Temple University (LKSOM) shows that gains in functional recovery from optic nerve injuries may be possible, thanks to a molecule known as Lin28, which regulates cell growth.
a scene of two children that is darkened around the edges

New Method Gives Glaucoma Researchers Control Over Eye Pressure

febrero 24, 2020

Neuroscientists at the University of South Florida have become the first to definitively prove pressure in the eye is sufficient to cause and explain glaucoma.