Roger Tsien, Ph.D., winner of The Nobel Prize in Chemistry 2008
Breeding and Building Molecules to Spy on Cells and Tumors
Dr. Roger Tsien, an investigator and professor at the Howard Hughes Medical Institute and the University of California, San Diego, gave the fourth annual Sayer Vision Research Lecture on Wednesday, March 10, 2010 at 1:00pm in the Masur Auditorium, NIH Clinical Center. His topic was “Breeding and Building Molecules to Spy on Cells and Tumors.” See the videocast (NIH only).
Dr. Tsien was awarded the Nobel Prize for his contribution toward the discovery and development of green fluorescent protein (GFP). His work has developed GFP into a tool used by researchers worldwide to analyze the movements, positions, and interactions of tagged proteins within cells. Recently, fluorescent proteins have been used to visualize synaptic circuits, allowing researchers to map glial territories and follow glial cells and neurons over time in vivo.
Dr. Tsien’s research is at the interface of organic chemistry, cell biology, and neurobiology. He is best known for designing and building molecules that either report or perturb signal transduction inside living cells. Dr. Tsien is currently designing imaging and therapeutic molecules that specifically target cancer cells.
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