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Manuel B. Datiles III, M.D.

Manuel B. Datiles

National Eye Institute (NEI),
National Institutes of Health (NIH), Bethesda, MD.

  • Medical Officer
  • Senior Clinical Investigator


  • Cataract development, prevention, treatment
  • Lens imaging/monitoring systems, implantation
  • Diabetic cataracts and corneal disorders
  • Ocular graft versus host disease in stem cell transplants
  • Corneal wound healing, transparency, transplantation
  • Anterior eye segment disorders

Dr. Datiles currently sees eye patients as part of clinical trials and research studies at NIH, including an ongoing study of ocular graft-versus-host disease in recipients of adult stem cell transplants. His long-term research focuses on cataract development and clinical trials involving anti-cataract drugs. Dr. Datiles also collaborates with NEI lens researchers to study the genetic causes of cataracts, and with Johns Hopkins University researchers to study the aggregation of lens proteins, which may lead to cataract development.


Dr. Datiles is the author of more than one hundred scientific manuscripts and textbook chapters. He has also served as an ad hoc editorial board member and reviewer for major ophthalmology journals, including Archives of Ophthalmology, Ophthalmology and Investigative Ophthalmology & Visual Science.

Professional Highlights

  • Collaboration with NASA scientists, which resulted in the adaptation of an instrument used in space for the detection of cataracts in the medical clinic. This device is the first non-invasive early detection device for cataracts that detects damage to lens proteins in the eye. Test results from the device could serve as an early warning for people to reduce their cataract risk by making lifestyle changes, including decreasing sun exposure, quitting smoking, and controlling diabetes.
  • Lens protein and cataract studies, which have advanced researchers' understanding of the cataract development process, and are helping move forward the development of non surgical treatment for cataract.

The National Eye Institute (NEI), part of the National Institutes of Health, leads the federal government's research on the visual system and eye diseases. NEI supports basic and clinical science programs that result in the development of sight-saving treatments.

National Eye Institute
(301) 496-5248