PUBLIC NOTICE OF PROPOSED ACQUISITION
National Eye Institute / National Institute of Health

Announcement/Number:  EE21-004940

Post Date: July 16, 2021

Closing Response Date: July 26, 2021

Proposed Award Date: July 29, 2021

Project Title: Multiclamp 700B Systems

Contracting Office: National Eye Institute, Building 31, Room 6A52

Contact Point/Contracting Officer/Contract Specialist: Elaine Estrella, estrellaek@mail.nih.gov

North American Classification System (NAICS) Code (include): 334516

Classification Code: Analytical Laboratory Instrument Manufacturing 

 

BACKGROUND, PURPOSE AND OBJECTIVE:
The goal of the Laboratory of Retinal Ganglion Cell Biology is to understand Glaucoma. Glaucoma is the second leading cause of blindness in developed countries. It is a group of optic neuropathies characterized by the death of retinal ganglion cells (RGCs), leading to a specific deformation of the optic nerve head. Peripheral vision declines first in glaucoma, while central vision loss occurs much later. Elevated intraocular pressure (IOP) is one of the main risk factors in glaucoma, but it is not completely understood how elevated IOP kills RGCs. Several genes have been implicated in glaucoma pathogenesis but the search for other contributing genes continues. The purpose of our requirement is to purchase Multiclamp 700B order to perform patch clamp recording from retinal neurons. 

Salient Characteristics of this requirement includes:

  • External trigger command or user- programmable voltage threshold for rapid, automatic mode-switching between current and voltage-clamp.
  • Detects current or voltage oscillations and automatically disables or intelligently reduces compensation settings to protect the cell from damage.
  • Injects a compensatory current over a user-defined time course to maintain the membrane potential at a consistent level.
  • Rapidly switches between patch-clamp recording and high-speed current-clamp recording.
  • Performs the function of two patch-clamp, two current-clamp, or a combination of patch- and current-clamp amplifiers with two headstages.
  • Handles the large (±2V) command voltages required during electrochemistry recording.
  • Powerful commander software controls tremendous flexibility, including broad ranges of current passing and recording levels, extensive filtering options and multiple signal outputs. It also controls the patching process by providing automation of pipette offset, fast/slow electrode capacitance compensation, whole-cell capacitance compensation, series resistance correction, pipette capacitance neutralization and bridge balance
  • Software user interface allows easy set up, display output voltage (or resistance) and current (or Irms) for each channel.
  • Lab current set up is equipped with the same series of device that must be integrated to our current system.
     

PRODUCT SPECIFICATION:

Part#

Manufacturer

Description

Quantity

Unit of Measure

Multiclamp 700B

 

 

 

 

 

 

Molecular Devices

System includes the following:

Microelectrode Amplifier, resistor-feedback, computer controlled, two channels (2) Headstages (CV 7B) Region-specific power cord Accessory kit containing: USB Cable, Two Baseplates for attaching headstages to manipulator, Two HL-U Electrode Holders, Two Patch-1U Model Cells, two 1mm pins, 1 year warranty covering parts & labor

 

Other specification includes:

Computer – 1GHz or better processor, Windows XP Pro / 2000 / 98 SE or MAC OS x 10.4.6 (Tiger) – CD-ROM drive 512 MB RAM, 500 MB HD Space, 2 USB 1 Ports

Multi-Clamp Commander Software (included)

1

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PAYMENT

Payment will be made 30 days after goods/service is rendered to NIH.

 

AWARD TYPE     

Firm Fixed 

 

PLACES OF PERFORMANCE

NATIONAL EYE INSTITUTE/ NIH
49 CONVENT DRIVE
BLDG 49 RM 2A50
BETHESDA, MD 20892

 

BASIS OF AWARD

A determination by the Government not to compete this proposed contract acquisition based upon responses to the notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed. Information provided will be used to assess tradeoffs and alternatives available for the potential requirement and may lead to the development of a solicitation. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. Any solicitation resulting from the analysis of information obtained will be announced to the public in Federal Business Opportunities in accordance with the FAR Part 5. However, responses to this notice will not be considered adequate responses to a solicitation. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any nonproprietary technical information in any resultant solicitation(s).

Closing Statement: This notice is not a request for competitive proposals.  However, interested parties may identify their interest and capability to respond to this notice.  Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov 

A determination by the Government not to compete this proposed action based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by July 26, 2021 and must reference number EE21-004940. Responses may be submitted electronically to estrellaek@mail.nih.gov

“All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.”
 

Last updated: July 16, 2021