Retinal pigment epithelial (RPE) cells stained red by RPE65 antibody.
Dr. T. Michael Redmond of the NEI’s Laboratory of Retinal Cell and Molecular Biology, Section on Gene Regulation cloned RPE65, a protein necessary for processing vitamin A in the visual cycle. Genetic mutation in RPE65 causes one type of Leber Congenital Amaurosis (LCA), a group of degenerative diseases of the retina. LCA is the most common cause of congenital blindness in children. Read more