Chief
Contact Information:
Email (301) 451-1307
35 Convent Dr., Room 3F-233
Porter Neuroscience Research Center, Bldg 35
Bethesda,
Maryland
20892
Biography
Dr. Pahlberg received his Ph.D. from the University of Helsinki, Finland, in 2007. His doctoral work, under the supervision of Professor Kristian Donner, focused on the adaptive evolution of visual pigments, and molecular mechanisms optimizing signaling in rod photoreceptors. His postdoctoral work with Dr. A.P. Sampath at the University of Southern California and University of California Los Angeles, focused on how mechanisms in rod bipolar cells is modulated for optimal signal detection in the retina. His current work is aimed at elucidating how rod photoresponses are processed and parsed into the retinal circuitry, and thus how optimization of response transmission already at the first visual synapse is achieved, by integrating physiology with genetics.
Selected publications
Stacks DA, Bocchero U, DeRamus ML, Nguyen MN, Messinger J, Kraft TW, Pittler SJ, Pahlberg J. Selective knockout of murine glutamic acid-rich protein 2 significantly alters dark continuous noise in rod photoreceptors. J Physiol. 2025 Nov 25. doi: 10.1113/JP286548. PMID: 41292168.39(34)
Bocchero U, Pahlberg J. Origin of Discrete and Continuous Dark Noise in Rod Photoreceptors. (2023) eNeuro 10(11): doi: 10.1523/ENEURO.0390-23.2023. PMID: 37973380; PMCID: PMC10687842.
Campla CK, Bocchero U, Strickland R, Nellissery J, Advani J, Ignatova I, Srivastava D, Aponte AM, Wang Y, Gumerson J, Martemyanov K, Artemyev NO, Pahlberg J*, Swaroop A* (2022) Frmpd1 facilitates trafficking of G-protein transducin and modulates synaptic function in rod photoreceptors of mammalian retina. eneuro:ENEURO.0348-0322.202
Corinne Beier*, Ulisse Bocchero*, Lior Levy, Zhijing Zhang, Nange Jin, Stephen Massey, Cristophe Ribelayga, Kirill Martemyanov, Samer Hattar, Johan Pahlberg. Divergent outer retinal circuits drive image and non-image visual behaviors. Cell Reports(2022) 39(13):111003.
Invited Peer-Reviewed Book chapters and Review Articles:
Johan Pahlberg, Anurima Majumder, Nikolai O. Artemyev. Ex vivo functional evaluation of synaptic transmission from rods to rod bipolar cells in mice. In Methods in Molecular Biology: Mouse Retinal Phenotyping (2018) 1753:203-216.
Johan Pahlberg, Alapakkam Sampath. The mitigation of transduction and synaptic noise in sensory systems is key to setting detection threshold. Bioessays (2011) 33(6): 438-477.