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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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NEI-funded researchers “push the ENVLPE” with new virus-like particle to fix mutations causing blindness

New CRISPR gene editing approach may also be useful for treating other inherited diseases, such as cystic fibrosis and familial hypercholesterolemia
Retinal organoid

Researchers ‘seq’ and find a way to make pig retinal cells to advance eye treatments

Researchers have developed lab-grown pig retinal organoids to test stem cell replacement therapies for diseases that damage the eye's light-sensing photoreceptors.
eye with herpes stromal keratitis

Wayne State researchers find potential mechanism to protect against infection-induced vision impairment

Herpes stromal keratitis is a debilitating vision condition that occurs in response to a herpes infection in the eye.
eye image

Mount Sinai-led research team identifies underlying mechanisms of age-related dysfunction in glands crucial to eye function

A team led by researchers at Mount Sinai has identified in mice a potential therapeutic target for dry eye disease.
mouse

New study uncovers how genes influence retinal aging and brain health

Researchers at the Jackson Laboratories used mice with nine different genetic backgrounds to identify factors influencing eye aging, paving the way for eye-based diagnostics for neurodegenerative diseases
Diagram of the eye showing location of the lens.

FAU lands $1.9 million NIH grant for novel way to treat degenerative disease

Florida Atlantic University researchers Lisa A. Brennan and Marc Kantorow will determine the novel mechanisms that convert immature eye lens precursor cells into functional transparent cells.
Extracellular vesicle

Report on extracellular vesicles

A new report summarizes proceedings from an NEI workshop on extracellular vesicles (Evs) – cell-secreted nanoparticles that mediate cell-cell communication.

NEI study: New take on old marker of cell death

New findings from a National Eye Institute-led study add a twist on how a widely used cell death marker, annexin-V, can be interpreted in the lab and the clinic for tracking retinal cell death in eye diseases such as glaucoma.
optic nerves

Nerve regrowth in sight

UConn scientists led by Ephraim Trakhtenberg regrew optic nerves in mice through eye injections of fibronectin peptides (pieces of the larger protein).

UC Irvine-co-led study finds DNA damage is key factor in age-related macular degeneration

Study reveals how DNA damage, a hallmark of aging, compromises the retina’s function and accelerates vision loss. Targeting specific retinal cell types could lead to treatments that slow or stop progression.