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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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183 items
Neurons (green) and their supporting astrocytes (red), created in a petri dish from stem cells.

Cell-replacement Therapies for Visual System Disorders

Two translational studies at the Vanderbilt Eye Institute are targeting photoreceptors and retinal ganglion cells (RGCs) to restore vision through regeneration of the retina. The research is funded by the NEI Audacious Goals Initiative.
OCT image of a retina

New biomarkers may detect early eye changes that can lead to diabetes-related blindness

New biomarkers found in the eyes could unlock the key to helping manage diabetic retinopathy, and perhaps even diabetes, according to new research conducted at the Indiana University School of Optometry.
Two boys smile at camera. Dark spot in center of image represents vision loss from AMD.

HtrA1 augmentation is potential therapy for age-related macular degeneration

Research from the University of Utah explains why people with genetic variants may develop age-related macular degeneration (AMD) and identifies a potential therapeutic pathway for slowing disease progression.
eye anatomy graphic

Melanoma of the eye: preclinical tests show path toward treatment

Researchers at UAB have discovered a small molecule inhibitor that dampens the potent drivers of uveal melanoma.
Photoreceptor precursor cells (red) are shown with extended axons toward bipolar cells.

Audacious projects develop imaging technology to aid eye tissue regeneration

As regenerative therapies for blinding diseases move closer to clinical trials, the NEI's functional imaging consortium is pioneering noninvasive technologies to monitor the function of the retina’s neurons and their connections to the brain.

Micro-molded ‘ice cube tray’ scaffold is next step in returning sight to injured retinas

Researchers at the University of Wisconsin have developed a micro-molded scaffolding photoreceptor “patch” designed to be implanted under a damaged or diseased retina.
photoreceptors and retinal ganglion cells are shown on a video play button.

An artificial retina engineered from ancient protein heads to space

LambdaVision, the Farmington, Connecticut-based biotech firm that developed the artificial retina, is exploring optimizing production of an artificial retina in space, in a series of missions to the International Space Station.
Artist's rendering of photoreceptor signaling a retinal ganglion cell

Computer model fosters potential improvements to ‘bionic eye’ technology

Researchers at Keck School of Medicine of USC develop signals that could bring color vision and improved clarity to prosthesis for the blind.
Image shows cone cells, labeled in red.

Turning back the clock on a severe vision disorder

Scientists at the University of Pennsylvania School of Veterinary Medicine report findings of a gene therapy to treat a severe form of Leber congenital amaurosis, caused by mutations in the NPHP5 gene.
Retina model shows RPE cells, choroidal neovascularization-like pathology, vascular layer, PEG layer, Bruch's membrane, drusen

First-ever lab model of human eye offers hope for macular degeneration patients

NEI-funded research at the University of Rochester has led to the development of a 3D lab model that mimics the part of the human retina affected in age-related macular degeneration.