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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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239 items
Cross-sectional images of retina from retinoschisin-deficient mice, untreated and treated with XLRS gene therapy.

NEI Human Gene Therapy Trial for Retinoschisis Underway

The National Eye Institute (NEI) recently launched the first-ever human gene therapy trial for the vision disorder X-linked retinoschisis (XLRS). Researchers are conducting the trial at the National Institutes of Health Clinical Research Center in...
Degenerated RPE cells from mice with geographic atrophy are shown at left. Treating the mice with NRTIs protected the RPE cells. Photos courtesy of Jayakrishna Ambati, M.D.

HIV drugs show promise for “dry” AMD

A class of medications long used to curb HIV infection shows promise as a therapy for age-related macular degeneration (AMD), suggest findings from an NIH-funded study.
Grantee News

Birthday Matters for Wiring-Up the Brain’s Vision Centers

New study suggests that neurons in the developing brains of mice are guided by a simple but elegant birth order rule that allows them to find and form their proper connections.
Retinal pigment epithelium derived from induced pluripotent stem cells. Photo credit: Dr. Kapil Bharti.

Gene profiling technique to accelerate stem cell therapies for eye diseases

Researchers at the National Institutes of Health have developed a technique that will speed up the production of stem-cell derived tissues.
Chichilnisky and colleagues used an electrode array to record activity from retinal ganglion cells (yellow and blue) and feed it back to them, reproducing the cells' responses to visual stimulation. Credit: E.J. Chichilnisky, Stanford.

Making artificial vision look more natural

In laboratory tests, researchers have used electrical stimulation of retinal cells to produce the same patterns of activity that occur when the retina sees a moving object.
Individual cilia grow from the basal body of a cell with assistance from distal and subdistal appendages (Credit: Shobi Veleri, Ph.D., National Eye Institute)

NIH study reveals gene critical to the early development of cilia

Researchers at the National Eye Institute (NEI) have described the functions of a gene responsible for anchoring cilia — sensory hair-like extensions present on almost every cell of the body.
Grantee News

Researchers Use Human Stem Cells to Create Light-Sensitive Retina in a Dish

Using a type of human stem cell, researchers have created a three-dimensional complement of human retinal tissue in the laboratory, which notably includes functioning photoreceptor cells capable of responding to light
Grantee News

JHU Biologists Identify New Neural Pathway in Eyes that Aids in Vision

A type of retina cell plays a more critical role in vision than previously known, a team led by Johns Hopkins University researchers has discovered.
Grantee News

IU School of Optometry study: New technique detects microscopic diabetes-related eye damage

Indiana University researchers have detected new early-warning signs of the potential loss of sight associated with diabetes. This discovery could have far-reaching implications for the diagnosis and treatment of diabetic retinopathy
To learn more about AGI, please visit www.nei.nih.gov/audacious/.

NEI announces funding for new imaging technology to support Audacious Goal

The National Eye Institute has announced a funding opportunity for imaging cells and tissues of the visual system.