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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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Grantee News

Seeing in a New Light

Researchers have used fruit flies and mice to make novel discoveries about sensory physiology at both cellular and molecular levels that are important for light processing.
Dr. John Guy and colleagues added a homing signal to a virus in order to deliver the ND4 gene into mitochondria. A marker for the gene is shown in red and the ND4 protein is shown in green, inside retinal ganglion cells in the mouse eye. The nuclei of retinal ganglion cells are shown in blue. Credit: Dr. Hong Yu, Bascom Palmer.

Scientists Test New Gene Therapy for Vision Loss From a Mitochondrial Disease

Researchers funded by the National Institutes of Health have developed a novel mouse model for the vision disorder Leber hereditary optic neuropathy (LHON), and found that they can use gene therapy to improve visual function in the mice.
Grantee News

How the Retina Marches to the Beat of Its Own Drum

Researchers at Johns Hopkins and the University of Washington report new research that sheds light on how the retina sets its own biological rhythm using a novel light-sensitive pigment, called neuropsin, found in nerve cells at the back of the eye.
The findings suggest that people may be able to lower their risk of AMD by eating a healthy diet, exercising and by not smoking.

Diet, Exercise, Smoking Habits and Genes Interact to Affect AMD Risk

People with a genetic predisposition for age-related macular degeneration (AMD) significantly increased their odds of developing the blinding eye disorder if they had a history of smoking and did not exercise or eat enough fruits and vegetables.
Grantee News

Identified Genetic Interaction Offers Possible New Target for Glaucoma Therapy

Scientists at the University of California, San Diego School of Medicine have elucidated a genetic interaction that may prove key to the development and progression of glaucoma.
Object motion and amacrine cells in retina

Circuit in the Eye Relies on Built-In Delay to See Small Moving Objects

When we move our head, the whole visual world moves across our eyes. Yet we can still make out a bee buzzing by or a hawk flying overhead, thanks to unique cells in the eye called object motion sensors.
Schematic of microbiota interacting with ocular immune system.

In Uveitis, Bacteria in Gut May Instruct Immune Cells to Attack the Eye

The inflammatory eye disorder autoimmune uveitis occurs when a person’s immune system goes awry, attacking proteins in the eye.
Grantee News

New clues found to vision loss in macular degeneration​​​

Scientists at Washington University School of Medicine in St. Louis have identified a pathway that leads to the formation of atypical blood vessels that can cause blindness in people with age-related macular degeneration.
Mice with AQP0 mutations (top) had disorderly fiber cells compared to mice with healthy AQP0.

Defective Lens Protein Implicated in Cataract Shown Culprit in Presbyopia

Loss or defects of a protein previously shown to play a key a role in cataract, the clouding of the lens that commonly strikes people in their seventies, has now been shown to contribute to presbyopia.
A microglial cell (green) extends spider-like arms to capture and consume rod photoreceptor cells (blue). Credit: Dr. Wai Wong, NEI.

In Blinding Eye Disease, Trash-Collecting Cells go Awry, Accelerate Damage

Spider-like cells inside the brain, spinal cord and eye hunt for invaders, capturing and then devouring them. These cells, called microglia, often play a beneficial role by helping to clear trash and protect the central nervous system against infection.