NEI Research News

Research from University of Michigan scientists reveals Vegf-Notch signaling system that is activated in the injured retina, gives Muller glia stem cell properties.

A pilot study of 106 patients with “wet” AMD revealed that nearly half of patients treated with Eylea could safely stop therapy after one year, compared to only 17% of patients treated with Avastin.

Rogue clinics offer stem cell-based therapies that haven’t been tested for safety and efficacy. When communicating to the public about stem cell-based therapies, it is important to put any treatment claims in context.

Columbia University researchers examined what goes wrong in the eyes of mice with albinism.

Using a new stem-cell based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).

Scientists have discovered a mechanism by which an area of a protein shape-shifts to convert vitamin A into a usable form for the eye’s light-sensing photoreceptor cells.

A basic research study from the National Eye Institute (NEI) explains how the molecule transducin moves within light-sensing rod photoreceptors in mouse retina to help the eye quickly adapt from bright to low light and back.

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus.

The protocol gives step-by-step instructions, starting with patient-derived pluripotent stem cells, transitioning them to retinal pigment epithelium (RPE) cells and finally maturing them into RPE tissue.

Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood.