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Safety and Effectiveness Research

Proposed human application leads to proven clinical application.

The NEI supports a number of activities to bridge the gap between the proposed human application of a discovery, and new medicines, devices, or surgeries work in people. NEI also collaborates with the Food and Drug Administration (FDA) to facilitate the ophthalmic regulatory approval process.

Age-Related Eye Disease Study (AREDS) logo

The Age-Related Eye Disease Study (AREDS) is a major clinical trial sponsored by the NEI to evaluate the effect of nutritional supplements on the progression of age-related macular degeneration (AMD) and cataract.

The NEI uses a number of funding mechanisms to support clinical trials through conception, protocol development, recruitment and retention, treatment and follow-up, and close out. NEI also supports research networks to facilitate clinical trials in specific disease areas, such as pediatric eye disease and diabetic retinopathy.

Last updated: July 24, 2019