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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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IL-17A acts on Th17 cells to produce anti-inflammatory response

Dual role discovered for molecule involved in autoimmune eye disease

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a new NEI study.
Bob Nussenblatt

NEI Remembers Robert “Bob” Nussenblatt (1948-2016)

Robert Nussenblatt, M.D., chief of the Laboratory of Immunology at the National Eye Institute (NEI), died on April 17 at age 67.
Eyes with autoimmune uveitis show increased inflammatory cells in the eye (indicated by arrows). Treatment with p35 reduces this inflammatory response. Credit: Charles Egwuagu.

NIH researchers unleash therapeutic potential of IL-35

NIH scientists have simplified manufacturing and dosing of a potential drug candidate for the autoimmune eye disease uveitis—a vision-threatening condition that accounts for about 15 percent of blindness in the U.S.
C. mast is a commensal bacterium living on the surface of the eye

Eye microbiome trains immune cells to fend off pathogens in mice

Bugs in your eyes may be a good thing. Resident microbes living on the eye are essential for immune responses that protect the eye from infection, new research shows.
Schematic of microbiota interacting with ocular immune system.

In Uveitis, Bacteria in Gut May Instruct Immune Cells to Attack the Eye

The inflammatory eye disorder autoimmune uveitis occurs when a person’s immune system goes awry, attacking proteins in the eye.
Two boys smile at camera. Dark spot in center of image represents vision loss from AMD.

NIH study suggests immune system could play a central role in AMD

Changes in how genes in the immune system function may result in age-related macular degeneration (AMD), the leading cause of visual impairment in older adults, based on preliminary research conducted by National Institutes of Health (NIH) investigators.
National Eye Institute logo.

NIH Researchers Discover Promising New Therapy for Blinding Eye Disease

A preliminary clinical trial, conducted by researchers at the National Institutes of Health (NIH), found that an investigational treatment for uveitis seems to have many fewer side effects than existing therapies
National Eye Institute logo.

New Eye Disease Treatment May Improve Patients' Quality of Life

In a small preliminary study, researchers at the National Institutes of Health (NIH) have discovered a possible new treatment for uveitis, a potentially blinding eye disease.

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