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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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140 items
Grantee News

Identified Genetic Interaction Offers Possible New Target for Glaucoma Therapy

Scientists at the University of California, San Diego School of Medicine have elucidated a genetic interaction that may prove key to the development and progression of glaucoma.
A microglial cell (green) extends spider-like arms to capture and consume rod photoreceptor cells (blue). Credit: Dr. Wai Wong, NEI.

In Blinding Eye Disease, Trash-Collecting Cells go Awry, Accelerate Damage

Spider-like cells inside the brain, spinal cord and eye hunt for invaders, capturing and then devouring them. These cells, called microglia, often play a beneficial role by helping to clear trash and protect the central nervous system against infection.
Grantee News

A World Without Color – Researchers Find Gene Mutation That Strips Color, Reduces Vision

Researchers have identified a previously unknown gene mutation that underlies achromatopsia, an inherited eye disorder.
A pronghorn antelope in the Grand Teton National Park captured by a DSLR camera using the image stabilization function (left). The image on the right was artificially blurred to simulate one’s vision without the work of direction-sensitive ganglion cells. Photo is courtesy of Lu O. Sun, Johns Hopkins Medicine.

The Brain’s Autofocus System Helps Stabilize Vision Despite Motion

Much like the automatic focus of a camera, our eyes and brains must constantly recalibrate so that we can get a clear view of the changing—and always moving—world around us.
Leaders from the University of Philippines (UP) and Philippine NIH (PNIH) met with NEI staff in May 2015. From L to R: Dr. Fielding Hejtmancik; Dr. Marie Carmela M. Lapitan, director of research management and translation, PNIH; Dr. Arlene Samaniego, vice chancellor, UP; Dr. Eva Maria Cutiongco-de la Paz, vice chancellor for research and executive director, PNIH; Dr. Belinda Seto; Dr. Carmencita Padilla; Dr. Paul A. Sieving; Dr. Gyan Prakash, Dr. Patricia Cabrera; and Dr. Manuel Datiles.

Dr. Patricia Cabrera: Learning Genetics and Linking NEI to the Philippines

A delegation from the University of the Philippines (UP) and the Philippine National Institutes of Health recently visited NEI on May 21, 2015. It was an opportunity to renew old collaborations and discuss new ones...
Grantee News

Plugging In Your Vision's Autostabilization Feature

New research, published online May 7 in the journal Neuron, describes how axons of specialized nerve cells find their way through the brain’s maze of neurons to make the right connection.
LCA is an inherited disorder that causes vision loss in childhood. It primarily affects the functioning of the retina, the light-sensitive tissue at the back of the eye, as shown here. Photo credit: National Eye Institute

NIH-funded Study Points Way Forward for Retinal Disease Gene Therapy

Gene therapy for Leber congenital amaurosis (LCA), an inherited disorder that causes vision loss starting in childhood, improved patients’ eyesight and the sensitivity of the retina within weeks of treatment.
Grantee News

Rare Mutation Causes Vitamin A Deficiency and Eye Deformities

Researchers at the University of Michigan and UC Davis have solved a genetic mystery that has afflicted three unrelated families, and possibly others, for generations.
Cross-sectional images of retina from retinoschisin-deficient mice, untreated and treated with XLRS gene therapy.

NEI Human Gene Therapy Trial for Retinoschisis Underway

The National Eye Institute (NEI) recently launched the first-ever human gene therapy trial for the vision disorder X-linked retinoschisis (XLRS). Researchers are conducting the trial at the National Institutes of Health Clinical Research Center in...
Grantee News

LSU Health New Orleans Makes Discovery Key to Preventing Blindness and Stroke Devastation

Researchers at the Louisiana State University Neuroscience Center of Excellence have discovered gene interactions that determine whether cells live or die in such conditions as age-related macular degeneration and ischemic stroke.