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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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65 items
Mouse retinal blood vessels

‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye

Researchers turn back the biological hands of time, making adult cells revert to a primitive state with the potential to replace and repair retinal blood vessels.
Schematic showing how to produce iPS cells

NIH launches first U.S. clinical trial of patient-derived stem cell therapy to replace and repair dying cells in retina

Researchers at the National Eye Institute (NEI) are launching a clinical trial to test the safety of a novel patient-specific stem cell-based therapy to treat geographic atrophy, the advanced “dry” form of age-related macular degeneration.
Image of scanning electron micrograph

NIH, NIST researchers use artificial intelligence for quality control of stem cell-derived tissues

Researchers used artificial intelligence (AI) to evaluate stem cell-derived “patches” of retinal pigment epithelium (RPE) tissue for implanting into the eyes of patients with age-related macular degeneration (AMD), a leading cause of blindness.
Grantee News

A Road Map to Stem Cell Development

Johns Hopkins Medicine researchers report they have created a method of mapping how the central nervous system develops by tracking the genes expressed in cells.
Grantee News

IUPUI researchers re-create retinal microenvironment in a dish with human stem cells

IUPUI scientists have used retinal ganglion cells derived from human pluripotent stem cells to create models that better mimic the human retina.
A scanning electron micrograph image shows a polarized RPE monolayer on a biodegradable scaffold. The image is colored to highlight the scaffold in blue, three RPE cells (brown), and the apical processes of cells in RPE monolayer are light green.

NIH researchers rescue photoreceptors, prevent blindness in animal models of retinal degeneration

Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced “dry” form of age-related macular degeneration (AMD)...
A scale with left superior colliculus neurons more activated on left and right superior colliculus neurons less activated on the right, and scale weighed down to the left. Needle on scale points to “yes”, meaning detection of relevant event.

NIH researchers discover neural code that predicts behavior

Scientists at the National Eye Institute (NEI) have found that neurons in the superior colliculus, an ancient midbrain structure found in all vertebrates, are key players in allowing us to detect visual objects and events.
Ground squirrel curled up in a nest

NIH researchers develop 'hibernation in a dish' to study how animals adapt to the cold

Researchers at the National Eye Institute have discovered cellular mechanisms that help the 13-lined ground squirrel survive hibernation.
Retina organoids mimic the structure and function of the human retina to serve as a platform to study underlying causes of retinal diseases, test new drug therapies, and provide a source of cells for transplantation. credit: David Gamm, M.D., Ph.D., University of Wisconsin-Madison

NIH solicits next-generation retina organoids in prize competition

A competition for radical ideas in the fight against blindness will move to its next phase by challenging participants to build functioning human retina prototypes.

NIH discovery brings stem cell therapy for eye disease closer to the clinic

Scientists at the National Eye Institute (NEI) report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE) are essential for the survival of the retina’s light-sensing photoreceptors.