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Living Retina Achieves Sensitivity and Efficiency Engineers Can Only Dream About

September 28, 2021

In a pair of papers on retinal structure, Duke University neurobiologists have shown that the rigors of natural selection and evolution have shaped the retinas in our eyes just as this theory of optimization would predict.

University of Oregon researchers develop gene therapy for eye disease

August 3, 2021

Researchers have developed a new gene therapy that could eventually provide an alternative treatment for Fuchs’ endothelial corneal dystrophy, a genetic eye disease affecting roughly one in 2,000 people globally.
Neurons (green) and their supporting astrocytes (red), created in a petri dish from stem cells.

Cell-replacement Therapies for Visual System Disorders

July 30, 2021

Two translational studies at the Vanderbilt Eye Institute are targeting photoreceptors and retinal ganglion cells (RGCs) to restore vision through regeneration of the retina. The research is funded by the NEI Audacious Goals Initiative.
Eye is shown connected to visual processing regions of the brain via the optic nerve. Enlargement of retina shows photorecetors, biopolar cells and retinal ganglion cells.

Scientists discover gene therapy provides neuroprotection to prevent glaucoma vision loss

July 22, 2021

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma.
Photoreceptor precursor cells (red) are shown with extended axons toward bipolar cells.

Audacious projects develop imaging technology to aid eye tissue regeneration

April 21, 2021

As regenerative therapies for blinding diseases move closer to clinical trials, the NEI's functional imaging consortium is pioneering noninvasive technologies to monitor the function of the retina’s neurons and their connections to the brain.

Micro-molded ‘ice cube tray’ scaffold is next step in returning sight to injured retinas

April 21, 2021

Researchers at the University of Wisconsin have developed a micro-molded scaffolding photoreceptor “patch” designed to be implanted under a damaged or diseased retina.
Artist's rendering of photoreceptor signaling a retinal ganglion cell

Computer model fosters potential improvements to ‘bionic eye’ technology

April 9, 2021

Researchers at Keck School of Medicine of USC develop signals that could bring color vision and improved clarity to prosthesis for the blind.
Retina model shows RPE cells, choroidal neovascularization-like pathology, vascular layer, PEG layer, Bruch's membrane, drusen

First-ever lab model of human eye offers hope for macular degeneration patients

March 30, 2021

NEI-funded research at the University of Rochester has led to the development of a 3D lab model that mimics the part of the human retina affected in age-related macular degeneration.
Anti-VEGF treatment has greatly improved the prognosis for patients with AMD.

National Eye Institute launches data portal for macular degeneration research

March 17, 2021

The National Eye Institute (NEI) Data Commons now enables researchers to access data from patients with macular degeneration who participated in the Age-related Eye Disease Study 2 (AREDS2).

Yale team finds dozens of genes that block regeneration of neurons

March 2, 2021

In a massive screen of 400 mouse genes, Yale School of Medicine researchers have identified 40 genes actively involved in suppression of axon regeneration in central nervous system cells.