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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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LCA is an inherited disorder that causes vision loss in childhood. It primarily affects the functioning of the retina, the light-sensitive tissue at the back of the eye, as shown here. Photo credit: National Eye Institute

Eye-opening discovery about adult brain’s ability to recover vision

October 5, 2022

University of California, Irvine team demonstrates the adult brain has the potential to partially recover from inherited blindness.
Fluorencent microscope image of retinal organoid colored in red, blue and green

Three teams win NIH’s 3D Retinal Organoid Challenge

August 31, 2022

Three scientific teams that developed physiologically competent retinal organoid systems have won the final phase of the 3D Retinal Organoid Challenge (3D ROC).
Photoreceptor precursors

Progress toward a stem cell–based therapy for blindness

July 28, 2022

A multi-institutional effort led by researchers at the UPenn School of Veterinary Medicine is taking steps to develop an effective technique to regenerate photoreceptors cells and restore sight in people with vision disorders.
NEI AGI audacious Goals Initiative for Regenerative Medicine

NEI's regenerative medicine initiative making progress toward its audacious goal

July 5, 2022

A new report outlines progress toward the National Eye Institute's Audacious Goals Initiative (AGI), an effort to restore vision through research in regenerative medicine. The report, published in Nature Medicine.

Life after death for the human eye

May 11, 2022

Scientists have revived light-sensing neuron cells in organ donor eyes and restored communication between them as part of a series of discoveries that stand to transform brain and vision research.

New UCI-led study lays foundation for establishing base editing as a one-time, durable treatment for inherited retinal degeneration

April 5, 2022

A new study indicates base editing may provide long-lasting retinal protection and prevent vision deterioration in patients with inherited retinal degeneration, specifically in Leber congenital amaurosis (LCA) patients.
Stained image of retina

Correcting night blindness in dogs

March 22, 2022

University of Pennsylvania researchers have developed a gene therapy that restores dim-light vision in dogs with a congenital form of night blindness, offering hope for treating a similar condition in people.
retina blood vessels

Indiana University-led study shows human induced pluripotent stem cells improve visual acuity, vascular health

March 17, 2022

Researchers improved vision in a type 2 diabetes mouse model by reprogramming blood cells into endothelial cells with vessel reparative properties similar to endothelial colony forming cells.
Artist's rendering of photoreceptor signaling a retinal ganglion cell

Implanted chip, natural eyesight coordinate vision in study of macular degeneration patients

February 4, 2022

A Stanford scientist and his colleagues show that patients fitted with a chip in their eye are able to integrate what the chip “sees” with objects their natural peripheral vision detects.
Cone photoreceptors from retinal organoids

UW study finds photoreceptor cells from retinal organoids can replicate key function of vision

February 2, 2022

Researchers from the U. of Wisconsin have shown that a retinal cell type derived from human pluripotent stem cells is capable of the complex process of detecting light and converting that signal to electrical waves.

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