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22 items

Yale team finds dozens of genes that block regeneration of neurons

March 2, 2021

In a massive screen of 400 mouse genes, Yale School of Medicine researchers have identified 40 genes actively involved in suppression of axon regeneration in central nervous system cells.

A new vision for AAV-delivered gene therapies

February 10, 2021

A broadly applicable AAV genome-coupled immunomodulation strategy helps cloak the AAV virus from unwanted immune responses, and offers important insights into ocular inflammation.

Cold Sores: Here’s How Stress, Illness and Even Sunburn Trigger Flareups

February 10, 2021

Researchers at the UVA School of Medicine have shed light on what causes herpes simplex virus to flare up, explaining how stress, illness and even sunburn can trigger unwanted outbreaks.

HIV Drugs May Help Prevent Blinding Macular Degeneration

February 1, 2021

Scientists have identified a group of drugs that may help stop a leading cause of vision loss after making an unexpected discovery that overturns a fundamental belief about DNA.

Discovery Of New Cell May Be Key To Treating Incurable Neurological Diseases

October 26, 2020

Researchers at Ohio State and the University of Michigan discovered a new type of immune cell that not only rescues damaged nerve cells from death, but partially reverses nerve fiber damage.

Therapy using immune system cells preserves vision in mice implanted with rare eye cancer

October 12, 2020

A treatment that uses immune system T-cells, combined with an immune-boosting drug packaged in an injectable gel, was found to preserve the vision of mice implanted with tissue from a human eye cancer known as retinoblastoma.
Colorful confocal image of endothelial cells and microglia

New treatment targets found for blinding retinal disease

August 10, 2020

When the eye isn’t getting enough oxygen in the face of common conditions like premature birth or diabetes, it can result in blindness. Scientists have identified new points where they may be able to enable recovery.
IL-17A acts on Th17 cells to produce anti-inflammatory response

Dual role discovered for molecule involved in autoimmune eye disease

July 23, 2020

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a new NEI study.
Grantee News

Antibody-based eye drops show promise for treating dry eye disease

October 11, 2019

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid.
Grantee News

New Treatment for Severe Dry Eye Disease Promising in Early Clinical Trials

May 7, 2019

Participants in a phase I/II clinical trial of a new enzyme-based treatment for severe dry eye disease experienced reduced signs of disease and discomfort, according to a paper in Translational Vision Science and Technology.