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20 items
Multicolor image of retina in cross-section

Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents

July 7, 2020

In experiments in rats and mice, two Johns Hopkins scientists report the successful use of nanoparticles to deliver gene therapy for blinding eye disease.
Cross-section of mouse eye showing lens, non-pigmented ciliary epithelium (green with sections of red at 12 o’clock and 6 o’clock), and zonular fibers (blue). Green corresponds to fibrillin-depleted NPCE. The space between the arrows indicates where the zonular fibers have snapped.

New research on Marfan syndrome focuses on eyes

June 12, 2020

New NEI-supported research provides insight into the eye conditions associated with Marfan syndrome, where weakened zonule fibers cause vision problems.
Surface-dwelling fish with an eye, and pale cave fish without eye

Gene Found that Causes Eyes to Wither in Cavefish

June 2, 2020

University of Maryland-led study identified the first gene responsible for eye loss in cavefish, revealing connection to a human vascular disease.
7 men look at the camera in a group portrait

NEI Researchers Awarded Grants by the Knights Templar Eye Foundation

July 11, 2019

The Knights Templar Eye Foundation has awarded two NEI scientists grants to research inherited retinal degenerations, diseases that can cause blindness in early childhood.
Photos of study participant with pale hair, left, and darker hair, right.

Nitisinone Increases Melanin in People With Albinism

February 20, 2019

A small pilot clinical study at the National Eye Institute (NEI) suggests that the drug nitisinone increases melanin production in some people with oculocutaneous albinism type 1B (OCA-1B), a rare genetic disease that causes pale skin and hair and poor vi
Grantee News

New study offers hope for patients suffering from a rare form of blindness

October 31, 2018

A new form of therapy may halt or even reverse a form of progressive vision loss, spinocerebellar ataxia type 7 (SCA7). This new therapy has the potential to treat neurogenetic diseases effectively and with far fewer side effects than other medications.
Illustration of icosahedral virus capsid, containing circular AAV vector. Arrows point from green and blue colored regions of the vector to shRNA and rhodopsin protein, respectively.

Researchers find potential new gene therapy for blinding disease

August 20, 2018

Scientists funded by the National Eye Institute (NEI) report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP).
James Golladay and Aman George hold up grant award check

Knights Templar Eye Foundation awards research grant to NEI scientist

June 21, 2018

National Eye Institute (NEI) Postdoctoral Fellow Aman George, Ph.D., has received a $65,000 grant from the Knights Templar Eye Foundation to identify new drug treatments for vision impairment in children with a type of albinism.
Field of green microglia on black background

Immune cells in the retina can spontaneously regenerate

March 21, 2018

Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a new study in mice from scientists at the National Eye Institute (NEI).
Xu Wang with Wai Wong in lab

Breast cancer drug dampens immune response, protecting light-sensing cells of the eye

March 13, 2017

The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice.