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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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149 items
Grantee News

New imaging technique by IU researchers could improve the diagnosis, treatment of glaucoma

New ophthalmoscopy method obtains high-definition, high-contrast images of translucent cells where the disease originates.
Aqueous humor flows out of the anterior chamber through the open angle where the cornea meets the iris. The open angle consists of two routes: the conventional, trabecular pathway, which includes a spongy layer called the trabecular meshwork, and the non-conventional, uveoscleral pathway, through the ciliary muscle that controls the eye’s focusing mechanism. The majority of fluid flows out via the trabecular pathway, which acts like a one-way valve. About a third of the fluid exits through the uveoscleral p

NEI support paved early pathway for novel glaucoma therapies

The recent approval of two novel medications for glaucoma – the first new medications for the disorder in nearly 18 years – are fruit borne from decades of foundational scientific research supported by the National Eye Institute (NEI).

NIH discovery brings stem cell therapy for eye disease closer to the clinic

Scientists at the National Eye Institute (NEI) report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE) are essential for the survival of the retina’s light-sensing photoreceptors.
Artist's rendering of photoreceptor signaling a retinal ganglion cell

Moving future regenerative therapies for blinding eye diseases to the clinic

A new report outlines steps to bringing future regenerative therapies for blinding diseases of the retina to patients. The retina is the light-sensitive tissue in the back of the eye. When stimulated, retinal neurons send visual information to the brain.
Eye

Helping the retina regenerate

A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain.
Xu Wang with Wai Wong in lab

Breast cancer drug dampens immune response, protecting light-sensing cells of the eye

The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice.
Grantee News

New Method to Detect Ultrasound with Light

A tiny, transparent device that can fit into a contact lens has a bright future, potentially helping a range of scientific endeavors from biomedicine to geology.
Grantee News

Retinitis Pigmentosa May Be Treated by Reprogramming Sugar Metabolism

NEI-funded researchers at Columbia University Medical Center have shown that vision loss associated with a form of retinitis pigmentosa can be slowed dramatically by reprogramming the metabolism of photoreceptors, or light sensors, in the retina.
Artist’s rendering of neural activity in the retina. Light that enters the eye activates rod and cone photoreceptors, which then activates retinal ganglion cells. A signal travels to the brain via the retinal ganglion cell axons. Photo credit: National Eye Institute

Six teams seek to identify biological factors that influence neural regeneration

The National Institutes of Health will fund six projects to identify biological factors that affect neural regeneration in the retina.
Retinal degeneration in mice

Drugs already on market prevent light-induced retinal degeneration in mice

Combinations of Food and Drug Administration-approved drugs protect against the loss of cells required for vision in a mouse model of blinding retinal diseases.