About our work
The Visual Decision Making Section seeks to help uncover the mechanisms and circuitry of visually guided decision-making. How are such decisions influenced by behavioral and cognitive context? How do neuromodulatory circuits influence the encoding of the incoming visual signals in the visual cortex? How are these combined signals used to guide behavior in healthy mammalian brains? Answering these questions is aimed at improving our understanding of how these mechanisms fail in psychiatric and neurological diseases. To address these questions we combine computational, behavioral, pharmacological, optogenetic and large-scale electrophysiological approaches in mammals, and, through collaboration, machine-learning techniques.
Selected publications
Quinn, Seillier, Butts, Nienborg, Decision-related feedback in visual cortex lacks spatial selectivity Nat Commun (2021) 12, Article number: 4473
Nienborg, Meyer Neuroscience needs behavior: inferring psychophysical strategy trial-by-trial. Neuron (2021) 109:561-563 doi:https://doi.org/10.1016/j.neuron.2021.01.025
Macke, Nienborg Choice (-history) correlations in sensory cortex: cause or consequence? Current Opin Neurobiol (2019) 58:148-154. doi: 10.1016/j.conb.2019.09.005
Bellet ME, Bellet J, Nienborg, Hafed, Berens Human-level saccade detection performance using deep neural networks. J Neurophysiol. (2019) 121:646-661.
Kawaguchi, Clery, Seillier, Pourriahi, Haefner, Nienborg: Differentiating between Models of Perceptual Decision Making Using Pupil Size Inferred Confidence J Neurosci (2018) 38:8874-8888.
Jacob, Nienborg: Monoaminergic neuromodulation of sensory processing Front Neural Circuits (2018) 10;12:51. doi: 10.3389/fncir.2018.00051
Bi, Jin, Nienborg, Xiao: Estimating cloth stiffness from videos using dense motion trajectories psychophysics and machine learning Journal of Vision (2018) 18:12.
Naselaris, Bassett, Fletcher, Kording, Kriegeskorte, Nienborg, Poldrack, Shohamy, Kay: Cognitive Computational Neuroscience: A New Conference for an Emerging Discipline. Trends in Cognitive Sciences (2018) 22:365-367.
Lueckmann, Macke*, Nienborg*: Can serial dependencies in choices and neural activity explain choice probability? J Neurosci, (2018) 38:3495-3506.
Seillier*, Lorenz*, Kawaguchi, Ott, Nieder, Pourriahi, Nienborg: Serotonin decreases the gain of visual responses in awake macaque V1 J Neurosci, (2017): 37:11390-405 (* equal contribution)
Clery, Cumming, Nienborg: Decision-Related Activity in Macaque V2 for Fine Disparity Discrimination Is Not Compatible with Optimal Linear Readout. J Neurosci, (2017): 37:715-25
Cumming, Nienborg: Feedback and feedforward sources of choice-probability in neural population responses. Current Opin Neurobiol, (2016): 37: 126-32
Nienborg, Roelfsema: Belief states as a framework to explain extra-retinal influences in visual cortex. Current Opin Neurobiol, (2015): 32: 45-52.
Nienborg, Cumming: Decision-related activity in sensory neurons may depend on the columnar architecture of cerebral cortex. J Neurosci, (2014): 34: 3579-85.
Nienborg, Hasenstaub, Nauhaus, Taniguchi, Huang, Callaway: Contrast dependence and differential contributions of somatostatin and parvalbumin expressing neurons to spatial integration in mouse V1. J Neurosci, (2013): 33: 11145-54.
Nienborg*, Cohen*, Cumming: Decision-Related Activity in Sensory Neurons: Correlations among Neurons and with Behavior. Ann Rev Neurosci (2012): 35:463-83 *equal contribution
Nienborg, Cumming: Correlations between the activity of sensory neurons and behavior: how much do they tell us about causality? Current Opin Neurobiol, (2010): 20:376-81
Nienborg, Cumming: Decision-related activity in sensory neurons reflects more than a neuron’s causal effect. Nature, (2009): 459:89-92
Nienborg, Cumming: Psychophysically measured task strategy for disparity discrimination is reflected in V2 neurons. Nature Neuroscience, (2007): 10:1608-14
Nienborg, Cumming: Macaque V2 neurons, but not V1 neurons, show choice-related Activity. J Neurosci, (2006): 26:9567-78
Nienborg, Bridge, Parker, Cumming: Neuronal Computation of Disparity in V1 Limits Temporal Resolution for Disparity Modulation, J Neurosci, (2005): 25:10207-19
key staff
Name | Title | Phone | |
---|---|---|---|
Adam Lazere, B.S. | Postbaccalaureate IRTA | adam.lazere@nih.gov | 301-496-9375 |
Emily Meyer, B.S. | Postbaccalaureate IRTA | emily.meyer@nih.gov | 301-496-9375 |
Hendrikje Nienborg, M.D., Ph.D. | Investigator | hendrikje.nienborg@nih.gov | 301-496-3549 |