Skip to content

Brett Jeffrey, Ph.D.


Contact Information:


10 Center DR, Room 10C436
Bethesda, Maryland 20892


Dr. Jeffrey received a Bachelor of Electrical Engineering (Telecommunications) from the University of Central Queensland in Australia.  After working for a telecommunications company, his career sidestepped into clinical electrophysiology, first at Sydney Eye Hospital and then Great Ormond Street Hospital for Children in London, UK.  Dr. Jeffrey received a Ph.D. in retinal biology from the Flinders University of South Australia.  His graduate studies focused on understanding the role of omega-3 long-chain fatty acids, particularly docosahexaenoic acid, on retinal function.  He then went onto purse postdoctoral training in the lab of Eileen Birch, using psychophysics to understand human visual development. Dr. Jeffrey was named Head of the Visual function at the National Eye Institute in 2011.

Selected publications

Thavikulwat AT, Lopez P, Caruso RC, Jeffrey BG.  The effects of gender and age on the range of the normal human electro-oculogram.  Doc Ophthalmol 2015; 131(3): 177-188. doi: 10.1007/s10633-015-9514-x   PMID: 26474906

Flynn OJ, Cukras CA, Jeffrey BG. Characterization of rod function phenotypes across a range of age-related macular degeneration severities and subretinal drusenoid deposits.  Invest Ophthalmol Vis Sci: 2018 59(6):2411-2421.  doi: 10.1167/iovs.17-22874.                     PMID: 29847647

Cukras CA, Wiley HE, Jeffrey BG, Sen HN, Turriff A, Zeng Y, Camasamudram Vijayasarathy C, Marangoni D, Ziccardi L, Kjellstrom S, Hiriyanna S, Colosi P, Zhijian Wu Z, Bush RA, Wei LL, Sieving PA. Retinal AAV8-RS1 gene therapy for X-linked retinoschisis: Initial findings from a phase I/IIa trial by intravitreal delivery. Mol Ther 2018 26(9):2282-2294. doi: 10.1016/j.ymthe.2018.05.025. PMID: 30196853

Flynn OJ, Jeffrey BG. Scotopic contour integration and shape discrimination using radial frequency patterns.  Journal of Vision 2019:19(2):7,1-12.  doi: 10.1167/19.2.7   PMID: 30747948

Uddin D, Jeffrey BG, Flynn O, Wong W, Wiley H, Keenan T, Chew C, Cukras C.  Repeatability of scotopic sensitivity and dark adaptation with a Medmont dark-adapted chromatic perimeter in age-related macular degeneration.  Trans. Vis. Sci. Tech.. 2020; 9(7):31. doi:

Last updated: April 2, 2021