Deputy Branch Chief:

Research interests: congenital eye diseases, coloboma, albinism

Contact Information: 301-451-5954

10 Center Drive
Building 10, Room 10B11B
Bethesda, Maryland 20892

Biography

Dr. Tiziana Cogliati obtained her doctoral degree in Medicinal Chemistry from the University of Milan in Italy and her Ph.D. degree in Cell and Molecular Biology from Leiden University in the Netherlands. She completed her postdoctoral training at the University of Milan, School of Medicine and at the National Cancer Institute, NIH.

From 2003-2008, Dr. Cogliati was a faculty member in the School of Medicine and Biomedical Sciences at Queen’s University Belfast (QUB) in Northern Ireland, UK. In the Center for Vision Science of QUB, she pursued her research interest in retinal neurobiology and development. Her research group studied the cell biology of adult retinal stem cells and the transcriptional regulatory mechanisms which specify cell fate in the retina.

Dr. Cogliati returned to the NIH in 2009 and joined the National Eye Institute. She worked first as a staff scientist with Dr. Anand Swaroop in the Neurobiology, Neurodegeneration & Repair Laboratory where she participated in research on molecular determinants of retinal development, aging and disease, and on the application of stem cells for disease modeling and therapy. She is currently deputy chief of the Ophthalmic Genetics and Visual Function Branch, directed by Dr. Brian Brooks. Dr. Cogliati is involved in research projects aimed at understanding the biology and genetics underlying congenital eye diseases such as coloboma and albinism and in testing therapeutic approaches.

Selected publications

Jiang K, Fairless E, Kanda A, Gotoh N, Cogliati T, Li T, Swaroop A. Divergent Effects of HSP70 Overexpression in Photoreceptors During Inherited Retinal Degeneration. Invest Ophthalmol Vis Sci. 2020 Oct 1;61(12):25. doi: 10.1167/iovs.61.12.25.

Corso-Díaz X, Gentry J, Rebernick R, Jaeger C, Brooks MJ, van Asten F, Kooragayala K, Gieser L, Nellissery J, Covian R, Cogliati T, Mondal AK, Jiang K, Swaroop A.Genome- wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism. Cell Rep. 2020 Apr 21;31(3):107525. doi: 10.1016/j.celrep.2020.107525.

George A, Cogliati T, Brooks BP. Genetics of syndromic ocular coloboma: CHARGE and COACH syndromes. Exp Eye Res. 2020 Apr;193:107940. doi: 10.1016/j.exer.2020.107940. Epub 2020 Feb 4.

Kalaskar VK, Alur RP, Li LK, Thomas JW, Sergeev YV, Blain D, Hufnagel RB, Cogliati T, Brooks BP. High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Hum Mutat. 2020 Mar;41(3):678-695. doi: 10.1002/humu.23954. Epub 2019 Dec 9.

Onojafe IF, Megan LH, Melch MG, Aderemi JO, Alur RP, Abu-Asab MS, Chan CC, Bernardini IM, Albert JS, Cogliati T, Adams DR, Brooks BP. Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4945-4952. doi: 10.1167/iovs.16-20293.

Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A. In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations. Cell Rep. 2017 Jul 11;20(2):384-396. doi: 10.1016/j.celrep.2017.06.045.

Kim JW, Yang HJ, Brooks MJ, Zelinger L, Karakülah G, Gotoh N, Boleda A, Gieser L, Giuste F, Whitaker DT, Walton A, Villasmil R, Barb JJ, Munson PJ, Kaya KD, Chaitankar V, Cogliati T, Swaroop A. NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors. Cell Rep. 2016 Nov 22;17(9):2460-2473. doi: 10.1016/j.celrep.2016.10.074.

Kaewkhaw R, Swaroop M, Homma K, Nakamura J, Brooks M, Kaya KD, Chaitankar V, Michael S, Tawa G, Zou J, Rao M, Zheng W, Cogliati T, Swaroop A. Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFl1-ORSFl11. doi: 10.1167/iovs.15-17639.

Kooragayala K, Gotoh N, Cogliati T, Nellissery J, Kaden TR, French S, Balaban R, Li W, Covian R, Swaroop A.Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria. Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8428-36. doi: 10.1167/iovs.15-17901.

Yang HJ, Ratnapriya R, Cogliati T, Kim JW, Swaroop A. Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease. Prog Retin Eye Res. 2015 May;46:1-30. doi: 10.1016/j.preteyeres.2015.01.005. Epub 2015 Feb 7.

Last updated: December 8, 2020