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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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126 items
Retinal organoid

Researchers ‘seq’ and find a way to make pig retinal cells to advance eye treatments

Researchers have developed lab-grown pig retinal organoids to test stem cell replacement therapies for diseases that damage the eye's light-sensing photoreceptors.
Scientist examines Western blots in the laboratory.

Novel stem cell therapy repairs irreversible corneal damage in clinical trial

A clinical trial that tested an experimental stem cell treatment for blinding cornea injuries found the treatment was feasible and safe in 14 patients, and there was a high proportion of complete or partial success.
Diagram of the eye showing location of the lens.

FAU lands $1.9 million NIH grant for novel way to treat degenerative disease

Florida Atlantic University researchers Lisa A. Brennan and Marc Kantorow will determine the novel mechanisms that convert immature eye lens precursor cells into functional transparent cells.
Extracellular vesicle

Report on extracellular vesicles

A new report summarizes proceedings from an NEI workshop on extracellular vesicles (Evs) – cell-secreted nanoparticles that mediate cell-cell communication.
optic nerves

Nerve regrowth in sight

UConn scientists led by Ephraim Trakhtenberg regrew optic nerves in mice through eye injections of fibronectin peptides (pieces of the larger protein).
Eye illustration

ARPA-H announces funding for development of eye transplantation

ARPA-H announced the teams to receive awards from its Transplantation of Human Eye Allografts (THEA) program.

CRISPR gene editing promising for blinding disease retinitis pigmentosa

National Eye Institute-funded scientists using gene editing corrected a mutation in a mouse model of retinitis pigmentosa, an inherited blinding eye disorder. The gene editing strategy restored production of rhodopsin, and retinal function and structure

U. Washington computational model shows cortical implants unlikely to exceed normal human vision

NIH-funded researchers created a computational model that simulates the experience of a high-resolution implant. Their models suggests implants are unlikely to exceed normal human vision.
LCA is an inherited disorder that causes vision loss in childhood. It primarily affects the functioning of the retina, the light-sensitive tissue at the back of the eye, as shown here. Photo credit: National Eye Institute

Participants of pioneering CRISPR gene editing trial see vision improve

About 79% of clinical trial participants experienced measurable improvement after receiving experimental, CRISPR-based gene editing that is designed to fix a rare form of blindness.
Optic nerve

Seeing a path to nerve regeneration

UConn scientists find protein that stimulates regrowth of optic nerve cells.

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