NEI Research News

In a University of California, Irvine-led study, researchers have discovered small-molecule drugs with potential clinical utility in the treatment of age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP).

New UCLA research in mice suggests that “dormant” cone photoreceptors in the degenerating retina are not dormant at all, but continue to function, producing responses to light and driving retinal activity for vision.

Dr. David Kosub shares a first-hand experience of participating in the National Ophthalmic Disease Genotyping and Phenotyping Network (eyeGENE).

A new study reveals how photoreceptors grown from stem cells might extend biological wires, known as axons, to contact existing neurons.

Molecular and cellular changes in rod photoreceptors are detectable in a mouse model of retinal degeneration several days prior to observable morphological changes, according to researchers at the National Eye Institute.

University of Pennsylvania researchers have developed a gene therapy that restores dim-light vision in dogs with a congenital form of night blindness, offering hope for treating a similar condition in people.

Researchers at the University of California, Berkeley, have found that a drug once widely used to wean alcoholics off of drinking helps to improve sight in mice with retinal degeneration.

Inhibiting ceramide accumulation in the retina helps preserve the retina’s structure and function, and improves vision.

Understanding the key structural determinants of a highly specialized membrane in the eye could lead to new treatments.

International effort identified new and different causative gene variants for a group of diseases that can lead to severe vision loss or blindness.