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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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LCA is an inherited disorder that causes vision loss in childhood. It primarily affects the functioning of the retina, the light-sensitive tissue at the back of the eye, as shown here. Photo credit: National Eye Institute

NIH-funded Study Points Way Forward for Retinal Disease Gene Therapy

Gene therapy for Leber congenital amaurosis (LCA), an inherited disorder that causes vision loss starting in childhood, improved patients’ eyesight and the sensitivity of the retina within weeks of treatment.
Artist's rendering of neural activity in the retina. Light that enters the eye activates rod and cone photoreceptors, which in turn activate retinal ganglion cells. Signals travel to the brain via retinal ganglion cell axons. Photo credit: National Eye Institute.

NIH Launches Research to Gaze Deeply Into Your Eyes

Five bold projects will develop new technology to noninvasively image cells of the eye in unprecedented detail.The National Eye Institute (NEI) announced the awards as part of its Audacious Goals Initiative.
Eye Examination

Early Tight Blood Glucose Control Reduces Eye Surgeries in People with Type 1 Diabetes

People with type 1 diabetes who intensively control their blood glucose (blood sugar) early in their disease, versus those who do not, are 48 percent less likely to need eye surgery, and the total number of such surgeries is 37 percent less.
Grantee News

Rare Mutation Causes Vitamin A Deficiency and Eye Deformities

Researchers at the University of Michigan and UC Davis have solved a genetic mystery that has afflicted three unrelated families, and possibly others, for generations.
Grantee News

3D structure solved for vulnerable region of glaucoma-causing protein

Scientists at Georgia Tech have determined the three-dimensional structure of a key part of a protein that is associated with glaucoma and identified regions of this domain that correlate with severe forms of the disease.
Grantee News

Stem Cell Injection May Soon Reverse Vision Loss Caused By Age-Related Macular Degeneration

An injection of stem cells into the eye may soon slow or reverse the effects of early-stage age-related macular degeneration, according to new research from scientists at Cedars-Sinai.
Cross-sectional images of retina from retinoschisin-deficient mice, untreated and treated with XLRS gene therapy.

NEI Human Gene Therapy Trial for Retinoschisis Underway

The National Eye Institute (NEI) recently launched the first-ever human gene therapy trial for the vision disorder X-linked retinoschisis (XLRS). Researchers are conducting the trial at the National Institutes of Health Clinical Research Center in...
Grantee News

LSU Health New Orleans Makes Discovery Key to Preventing Blindness and Stroke Devastation

Researchers at the Louisiana State University Neuroscience Center of Excellence have discovered gene interactions that determine whether cells live or die in such conditions as age-related macular degeneration and ischemic stroke.
Grantee News

Results challenge conventional wisdom about where the brain begins processing visual information

Using high-resolution functional magnetic resonance imaging (fMRI), a team of researchers from Vanderbilt and Boston universities, have discovered that more complex processing occurs in the initial stages of the visual system than previously thought.
Grantee News

​Stem Cells from Wisdom Teeth Can Be Transformed into Corneal Cells

Stem cells from the dental pulp of wisdom teeth can be coaxed to turn into cells of the eye’s cornea and could one day be used to repair corneal scarring due to infection or injury.