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Hibernation in mammals is a seasonal state of metabolic suppression and dormancy characterized by a decrease in body temperature to survive extreme environmental stresses. Small hibernators such as 13-lined ground squirrels use this remarkable strategy to survive extreme environmental stresses like cold and restricted food supply.

Product: A new iPSC line from the neural precursor cells of wild type thirteen-lined ground squirrel (Spermophilus tridecemlineatus).

Use: This ground squirrel iPSC line can be differentiated into many different cell types for hibernation studies, disease modeling, and drug screening for neuronal injuries or other diseases

Competitive Advantage: This is the first iPSC line established from small hibernators like ground squirrel. These lines are useful in generating various cell types and tissue models for in-depth mechanistic studies of hibernation and coldness tolerance in vitro.

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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications Cell. 2018 May 3;173(4):851-863.e16. https://youtu.be/h-9DNX7urgE

For licensing: E-059-2017

Inventors: Jingxing Ou (NEI), Wei Lei (NEI)

Contact

Mala Dutta, Ph.D.
Office of Translational Research
301-451-2198
Last updated: May 18, 2020