miRNA or microRNA are small non-coding RNAs that regulate gene expression by repressing translation and degrading mRNAs. miRNA are involved in many critical biological processes and are implicated in the health and development of the eye.
Technology: Identifies miRNA201/211 as critical controllers of trans-epithelial electrical resistance, epithelial barrier-function, epithelial cell-differentiation, proliferation and migration with significant implication in disease.
Competitive Advantage: First functional information of miRNA enriched in human RPE and their direct targets. 204/211 identified as two most highly expressed miRNA. In vitro human fetal RPE data available. Potential in treatment of AMD, Proliferative Vitreal Retinopathy and Pulmonary Arterial Hypertension (PAH).
Intellectual Property: US Patents issued (US 8,455,454 and US 8,710,026). Technology available for co-development, non-exclusive/exclusive license consideration.
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