Senior Investigator
Head
Research interests: Molecular structure and functional genomics
Contact Information:
Email 301-402-3452
Building 6, Room 106
6 Center Drive
Bethesda,
Maryland
20892-0608
Biography
Dr. Wistow received his BA in Biochemistry from Oxford University, UK in 1976 and his Ph.D. in Protein X-ray crystallography from the University of London, UK in 1982. His thesis work described the first three-dimensional structure of a γ-crystallin. He joined NEI in 1982 and became a Section Chief in 1989. Dr. Wistow received NEI Director’s Awards in 1991 and 2000, an NEI Appreciation award in 2005 and an NIH Director’s Award in 2001. In 1997 he received the Cogan Award of the Association for Research in Vision and Ophthalmology "In recognition of outstanding and promising research on the structure and function of the lens".
Selected publications
Sagar, V. and Wistow, G. (2022) Acquired disorder and asymmetry in a domain-swapped model for g-crystallin aggregation. J. Mol. Biol. 434(9):167559.
Fan, J., Rajapakse, D., Peterson, K., Lerner, J., Parsa, S., Ponduri, A., Sagar, V., Duncan, T., Dong, L. and Wistow, G. (2021) Retbindin mediates light-damage in mouse retina while its absence leads to premature retinal aging. Exp Eye Res. 209:108698
Rajapakse, D., Peterson, K., Mishra, S., Fan, J., Lerner, J., Campos, M. and Wistow, G. (2020) Amelotin, a promoter of calcium mineralization, is induced by serum-deprivation in retinal pigment epithelial cells in culture and localizes to hydroxyapatite deposits in dry AMD. Transl. Res. 219:45-62.
Fan, J., Lerner, J., Wyatt, K.K., Cai, P, Peterson, K., Dong, L. and Wistow, G. (2018) The Klotho-related protein Klph (Lctl) has preferred expression in lens and is essential for expression of Clic5 and normal lens suture formation. Exp. Eye Res. 169:111-121.
Rajapakse, D., Peterson, K., Mishra, S. and Wistow G. (2017) Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of Age-related Macular Degeneration. Exp. Cell Res. 361(2):333-341