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New method enables long-lasting imaging of rapid brain activity in individual cells deep in the cortex

August 18, 2022

As you are reading these words, certain regions of your brain are displaying a flurry of millisecond-fast electrical activity. Visualizing and measuring this electrical activity is crucial to understand how the brain enables us to see, move, behave or read these words. However, technological limitations are delaying neuroscientists from achieving their goal of improving the understanding of how the brain works.

Scientists at Baylor College of Medicine and collaborating institutions report in the journal Cell a new sensor that allows neuroscientists to image brain activity without missing signals, for an extended time and deeper in the brain than previously possible. This work is paving the way to new discoveries on how the brain functions in awake, active animals both those that are healthy and those with neurological conditions.
The holy grail of neuroscience

“Not only is the brain’s electrical activity very fast, it also involves a variety of cell types that have different roles in brain computations,” said corresponding author, Dr. François St-Pierre, assistant professor of neuroscience and a McNair scholar at Baylor. He also is an adjunct assistant professor of electrical and computer sciences at Rice University. “It has been challenging to figure out how to noninvasively observe the millisecond-fast electrical activity in individual neurons of specific cell types in animals carrying on an activity. To be able to do this has been the holy grail of neuroimaging.”

Baylor co-authors Dr. Andreas Tolias, professor of neuroscience, and Dr. Jacob Reimer, assistant professor of neuroscience, demonstrated that their new technique, JEDI-2P, can report electrical activity in mice using imaging equipment available in many neuroimaging labs.