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Helper protein worsens diabetic eye disease

November 27, 2019
Blood vessels in the retina

Blood vessels in the retina. Image credit: Akrit Sodhi

In a recent study using mice, lab-grown human retinal cells and patient samples, Johns Hopkins Medicine scientists say they found evidence of a new pathway that may contribute to degeneration of the light sensitive tissue at the back of the eye. They found that angiopoietin-like 4, a signaling protein that is already well known to be a blood vessel growth factor with roles in heart disease, cancer and metabolic diseases, is at play in diabetic macular edema.